HYPERTENSION, OXIDATIVE STRESS AND RACE

高血压、氧化应激和种族

• 批准号: 7609673
• 负责人: ZHONGMAO GUO
• 金额: $ 10.91万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7609673
• 关键词: African American; Blood; Blood Cells; Blood Pressure; Caucasians; Caucasoid Race; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Condition; F2-Isoprostanes; Funding; Grant; High Blood Pressure; Hypertension; Institution; Measures; Oxidative Stress; Oxygen; Population; Purpose; Race; Reactive Oxygen Species; Reading; Research; Research Personnel; Resources; Source; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies show that hypertension, also known as high blood pressure, occurs more commonly in African-Americans than in Caucasians. For this reason, this study will focus on hypertension in African-Americans and examine factors that may cause hypertension to be found more often in this population. The factor that will be examined in this study is a condition known as oxidative stress. Oxidative stress is a condition where too much oxygen is produced in the blood and the cells begin to decline in quality. Two chemicals, such as, reactive oxygen species (ROS) and F2-isoprostane, when found in high levels in the blood, can cause this condition. The purpose of this study is to measure these chemicals and determine if African-Americans with high blood pressure have higher levels of these chemicals than in subjects with normal blood pressure readings.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 研究表明，高血压，也称为高血压，在非洲裔美国人中比白人更常见。 因此，这项研究将重点关注非裔美国人的高血压，并检查可能导致该人群更常见高血压的因素。 本研究将检查的因素是一种称为氧化应激的状况。 氧化应激是血液中产生过多氧气并且细胞质量开始下降的情况。 活性氧 (ROS) 和 F2-异前列腺素等两种化学物质在血液中含量较高时，可能会导致这种情况。 这项研究的目的是测量这些化学物质，并确定患有高血压的非裔美国人是否比血压正常的受试者体内这些化学物质的含量更高。