VENTRICULAR MYOCYTE FUNCTION IN HEALTH AND DISEASE

健康和疾病中的心室肌细胞功能

• 批准号: 7381218
• 负责人: JUN REN
• 金额: $ 10.77万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381218
• 关键词: aging; calcium; genes; health; heart; homeostasis; hypertension; intracellular; molecular biology; muscle cells; nitric oxide; obesity; physiology; stress; tissue /cell culture; transfection

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. My main research focus during the past year and since joining the COBRE has been to study the pathophysiology of abnormal cardiac excitation-contraction (E-C) coupling and impaired cell survival/signaling in diabetes, hypertension, obesity, and aging. My work focuses on whole heart, single ventricular myocyte function, cell culture, intracellular calcium homeostasis and various subcellular signaling pathways related to nitric oxide and various kinds of cell stress. Cellular physiology combined with molecular biology, transgene and gene transfer techniques are used to understand the mechanisms of action under these disease states.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。我的主要研究重点是在过去的一年中，自从加入毛病以来一直是研究异常心脏激发诱导（E-C）偶联（E-C）偶联的病理生理学，并在糖尿病，高血压，肥胖和衰老中研究细胞存活/信号。我的工作着重于全心，单个心室心肌功能，细胞培养，细胞内钙稳态以及与一氧化氮和各种细胞应激有关的各种亚细胞信号通路。细胞生理结合分子生物学，转基因和基因转移技术用于了解这些疾病状态下的作用机理。