SPROUTY ACTION IN HEMATOPOIETIC COMPARTMENTS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该项目拟研究Ras信号胞质抑制剂Spry1在骨髓基质和造血细胞生物学中调控FGF和其他生长因子的作用。该方法将采用中心内可用的新型小鼠模型。P. Sathyanarayana将与R. Friesel进行高度互动，后者将提供这些研究中使用的转基因小鼠。预计该项目还将与项目1 （V. Lindner）和项目2 （L. Liaw）进行互动，因为这两个项目都将解决炎症和炎症细胞因子调节方面的问题。同样，这个项目将与项目7和项目8的未来新兵进行互动。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project proposes to examine the role of Spry1, a cytoplasmic inhibitor of Ras signaling, in regulating the action of FGF and other growth factors in bone marrow stromal and hematopoietic cell biology. The approach will employ novel mouse models available within the Center. P. Sathyanarayana will be highly interactive with R. Friesel who will provide the transgenic mice employed in these studies. It is anticipated that this project with also be interactive with Project 1 (V. Lindner) and Project 2 (L. Liaw) as both projects will address aspects of inflammation and regulation of inflammatory cytokines. Likewise, this project will be interactive with the future recruits of Projects 7 and 8.