SPROUTY ACTION IN HEMATOPOIETIC COMPARTMENTS

造血室中的发芽作用

• 批准号: 7381072
• 负责人: Sheela Sathyanarayana
• 金额: $ 13.83万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381072
• 关键词: SPROUTY; ACTION; HEMATOPOIETIC; COMPARTMENTS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project proposes to examine the role of Spry1, a cytoplasmic inhibitor of Ras signaling, in regulating the action of FGF and other growth factors in bone marrow stromal and hematopoietic cell biology. The approach will employ novel mouse models available within the Center. P. Sathyanarayana will be highly interactive with R. Friesel who will provide the transgenic mice employed in these studies. It is anticipated that this project with also be interactive with Project 1 (V. Lindner) and Project 2 (L. Liaw) as both projects will address aspects of inflammation and regulation of inflammatory cytokines. Likewise, this project will be interactive with the future recruits of Projects 7 and 8.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目建议检查Spry 1（Ras信号传导的细胞质抑制剂）在调节FGF和其他生长因子在骨髓基质和造血细胞生物学中的作用。该方法将采用中心内现有的新型小鼠模型。P. Sathyanarayana将与R. Friendly将提供这些研究中使用的转基因小鼠。预计该项目还将与项目1（V. Lindner）和项目2（L。Liaw），因为这两个项目都将涉及炎症和炎症细胞因子调节的方面。同样，该项目将与项目7和8的未来新成员互动。