SPROUTY ACTION IN HEMATOPOIETIC COMPARTMENTS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project proposes to examine the role of Spry1, a cytoplasmic inhibitor of Ras signaling, in regulating the action of FGF and other growth factors in bone marrow stromal and hematopoietic cell biology. The approach will employ novel mouse models available within the Center. P. Sathyanarayana will be highly interactive with R. Friesel who will provide the transgenic mice employed in these studies. It is anticipated that this project with also be interactive with Project 1 (V. Lindner) and Project 2 (L. Liaw) as both projects will address aspects of inflammation and regulation of inflammatory cytokines. Likewise, this project will be interactive with the future recruits of Projects 7 and 8.