Melamine/Cyanuric Acid Exposure and Kidney Injury in Children

三聚氰胺/氰尿酸暴露与儿童肾脏损伤

基本信息

批准号：
10019551
负责人：
Sheela Sathyanarayana
金额：
$ 18.75万
依托单位：
SEATTLE CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-18 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10019551
关键词：
Acids Acute Renal Failure with Renal Papillary Necrosis Adhesives Adolescence Adult Affect Age Albumins Animal Feed Beta-N-Acetylglucosaminidase Beverages Cessation of life Chemical Exposure Chemicals Child Childhood Childhood Injury China Chronic Consumption Creatinine Crystallization Data Detection Development Dose Exhibits Exposure to Food Funding Future General Population Health Household Products Industrial Product Infant Infant formula Ingestion Injury to Kidney Investigation Kidney Kidney Diseases Knowledge LCN2 gene Lead Life Literature Liver Measures Melamine Microalbuminuria Nitrogen Outcome Plastics Policies Population Prevention Proteinuria Public Health Publishing Renal function Reporting Risk Sampling Serum Source System Time United States National Institutes of Health Urinary tract Urine chlorination cohort consumer product environmental chemical epidemiology study fast food fatty acid-binding proteins follow-up nephrotoxicity novel renal damage urinary urolithiasis

项目摘要

Abstract Melamine and cyanuric acid are environmental chemicals that are found in common household products and can cause kidney injury and damage. Widespread high dose contamination of infant formula with melamine and cyanuric acid led to significant illness and deaths among infants in China due to kidney toxicity, but few studies have examined if lower level chronic exposures may affect kidney health in children. This will be the first study to investigate background melamine and cyanuric exposures in US children and the first to determine their relationship with kidney injury markers. We will measure melamine and cyanuric acid in 800 urine samples from 600 children (600 samples at ages 4-6y and 200 samples at follow-up, ages 8-9y) in the PATHWAYS GAPPS (PWG) cohort, an active cohort funded through the NIH Environmental Influences on Child Outcomes (4UH3OD023271-03) mechanism. We will determine sources of exposure and conduct cross-sectional and longitudinal investigations of urinary melamine and cyanuric acid with urinary markers of renal injury and function: NGAL, NAG, KIM1, proteinuria, and microalbuminuria. The knowledge gained could lead to identification of a novel contributor to kidney injury and disease development. Study results could also be used to reduce exposures in the general population.

抽象的三聚氰胺和氰尿酸是在普通家庭中发现的环境化学物质产品并可能造成肾脏损伤和损害。广泛的高剂量污染双三聚氰胺和氰尿酸的婴儿配方奶粉导致重大疾病和死亡由于肾脏毒性而导致的中国婴儿，但是很少有研究检查较低水平的慢性暴露可能会影响儿童的肾脏健康。这将是第一个调查的研究背景三聚氰胺和氰尿道暴露在美国儿童中，第一个确定他们的儿童与肾脏损伤标记的关系。我们将在800中测量三聚氰胺和氰尿酸来自600名儿童的尿液样本（4-6岁时的600个样本和随访的200个样本，年龄 8-9y）在途径Gapps（PWG）队列中，由NIH资助环境对儿童结局（4UH3OD023271-03）机制的影响。我们将确定暴露源和进行横截面和纵向研究泌尿三聚氰胺和氰尿酸具有肾损伤和功能的尿标志物：ngal， NAG，KIM1，蛋白尿和微珠尿症。获得的知识可能导致确定肾脏损伤和疾病发育的新贡献者。研究结果也可以用来减少普通人群的暴露。