Melamine/Cyanuric Acid Exposure and Kidney Injury in Children

三聚氰胺/氰尿酸暴露与儿童肾脏损伤

• 批准号: 9809122
• 负责人: Sheela Sathyanarayana
• 金额: $ 22.5万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-18 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9809122
• 关键词: Acids; Acute Renal Failure with Renal Papillary Necrosis; Adhesives; Adolescence; Adult; Affect; Age; Albumins; Animal Feed; Beta-N-Acetylglucosaminidase; Beverages; Cessation of life; Chemical Exposure; Chemicals; Child; Childhood; Childhood Injury; China; Chronic; Consumption; Creatinine; Crystallization; Data; Detection; Development; Disease; Dose; Exhibits; Exposure to; Food; Funding; Future; General Population; Health; Household Products; Industrial Product; Infant; Infant formula; Ingestion; Injury; Injury to Kidney; Investigation; Kidney; Kidney Diseases; Knowledge; LCN2 gene; Lead; Life; Literature; Liver; Measures; Melamine; Microalbuminuria; Nitrogen; Outcome; Plastics; Policies; Population; Prevention; Proteinuria; Public Health; Publishing; Renal function; Reporting; Risk; Sampling; Serum; Source; System; Time; United States National Institutes of Health; Urinary tract; Urine; chlorination; cohort; consumer product; environmental chemical; epidemiology study; fast food; fatty acid-binding proteins; follow-up; nephrotoxicity; novel; renal damage; urinary; urolithiasis

Abstract Melamine and cyanuric acid are environmental chemicals that are found in common household products and can cause kidney injury and damage. Widespread high dose contamination of infant formula with melamine and cyanuric acid led to significant illness and deaths among infants in China due to kidney toxicity, but few studies have examined if lower level chronic exposures may affect kidney health in children. This will be the first study to investigate background melamine and cyanuric exposures in US children and the first to determine their relationship with kidney injury markers. We will measure melamine and cyanuric acid in 800 urine samples from 600 children (600 samples at ages 4-6y and 200 samples at follow-up, ages 8-9y) in the PATHWAYS GAPPS (PWG) cohort, an active cohort funded through the NIH Environmental Influences on Child Outcomes (4UH3OD023271-03) mechanism. We will determine sources of exposure and conduct cross-sectional and longitudinal investigations of urinary melamine and cyanuric acid with urinary markers of renal injury and function: NGAL, NAG, KIM1, proteinuria, and microalbuminuria. The knowledge gained could lead to identification of a novel contributor to kidney injury and disease development. Study results could also be used to reduce exposures in the general population.

摘要