INVESTIGATIONS OF THERMAL EFFECTS IN PHOTODYNAMIC THERAPY TO TREAT SOLID TUMORS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该项目旨在校准理论动态热损伤模型（DTDM），并确定激光热疗（LHT）治疗在动物模型（Balb/C小鼠）上治疗浅表恶性肿瘤的疗效。在2004年夏天（子项目期间），我们将主要集中在使用Diomed二极管激光器的LHT工作上。热探头（红外热像仪，热电偶）将在激光热疗治疗过程中产生局部温度（光纤尖端区域），表面温度和平均肿瘤温度。将进行定量组织学检查，以量化热损伤特征。DTDM模型将根据肿瘤温度场、损伤分布的预测及其与实验损伤数据（组织学）的比较进行校准。验证了该模型的有效性，并对低温热处理的损伤进行了预测。DTDM的主要目的是计算在联合LHT和PDT治疗中由于高温造成的损伤量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project aims at the calibration of the theoretical Dynamic Thermal Damage Model (DTDM) and to determine the efficacy of the Laser Hyperthermia (LHT) treatment to treat superficial malignant tumors on an animal model (Balb/C mice). During the summer of 2004 (the duration of the subproject), we will primarily concentrate on the LHT work using a Diomed Diode laser. Thermal probes (IR Thermal Camera, Thermocouples) will yield the local temperature (fiber tip zone), the surface temperature and the average tumor temperature during laser hyperthermia therapy. Quantitative histology will be performed to quantify the thermal damage profile. The DTDM model will be calibrated in light of the predictions of the temperature field of the tumor, damage profile, and its comparison with the experimental damage data (histology). The validity of the model will be ascertained to predict the LHT damage. The major purpose of the DTDM is to calculate the amount of damage due to hyperthermia in combined LHT and PDT treatments.