INVESTIGATIONS OF THERMAL EFFECTS IN PHOTODYNAMIC THERAPY TO TREAT SOLID TUMORS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目旨在对理论动态热损伤模型(DTDM)进行校正，并在动物模型(Balb/C小鼠)上确定激光热疗(LHT)治疗浅表恶性肿瘤的疗效。在2004年夏天(子项目的持续时间)，我们将主要集中在使用DIOMED半导体激光器的LHT工作上。在激光热疗过程中，热探头(红外热像仪、热电偶)将产生局部温度(纤维尖端区域)、表面温度和肿瘤平均温度。将进行定量组织学检查，以量化热损伤情况。DTDM模型将根据对肿瘤温度场、损伤轮廓的预测以及与实验损伤数据(组织学)的比较进行校准。用来预测LHT损伤的模型的有效性将得到验证。DTDM的主要目的是计算LHT和PDT联合治疗中高温造成的损伤量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project aims at the calibration of the theoretical Dynamic Thermal Damage Model (DTDM) and to determine the efficacy of the Laser Hyperthermia (LHT) treatment to treat superficial malignant tumors on an animal model (Balb/C mice). During the summer of 2004 (the duration of the subproject), we will primarily concentrate on the LHT work using a Diomed Diode laser. Thermal probes (IR Thermal Camera, Thermocouples) will yield the local temperature (fiber tip zone), the surface temperature and the average tumor temperature during laser hyperthermia therapy. Quantitative histology will be performed to quantify the thermal damage profile. The DTDM model will be calibrated in light of the predictions of the temperature field of the tumor, damage profile, and its comparison with the experimental damage data (histology). The validity of the model will be ascertained to predict the LHT damage. The major purpose of the DTDM is to calculate the amount of damage due to hyperthermia in combined LHT and PDT treatments.