INBRE: CLAFLIN U: FACULTY AND UNDERGRADUATE RESEARCH DEVELOPMENT

INBRE：CLAFLIN U：教师和本科生研究发展

• 批准号: 7381400
• 负责人: Rebecca Bullard-Dillard
• 金额: $ 43.02万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381400
• 关键词: INBRE; CLAFLIN; FACULTY; UNDERGRADUATE; RESEARCH

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Claflin University is located in Orangeburg, South Carolina, only 35 miles from the University of South Carolina (USC). Claflin University is the first HBCU in the state to start a Center for Biotechnology (The South Carolina Center for Biotechnology or SCCBT) as well as instituting a new Masters of Science (MS) program in Biotechnology. As a mentored institution of the SC-BRIN, Claflin established a state-of-the-art DNA sequencing facility. Claflin University benefited greatly by inclusion in the first phase of the SC-BRIN. Our administrators (in particular our President) are committed to developing a research program for the entire institution as a direct outcome of the SC-BRIN. We have already established collaborative links between five of our faculty and faculty at USC and Clemson University through the SC-BRIN and we are ready to step-up our research enterprise, assuring that our program will contribute to the overall success of the SC-INBRE. This application focuses on three research infrastructure building areas: 1) For Student Training we propose: a. Support for a total of 15 graduate student (MS) INBRE Research Fellows b. Support for a total of 18 academic year undergraduate research internships 2) For Faculty Development we request support for the development of two collaborative research projects involving two new tenure track faculty hires at Claflin. Dr. Jianguo Chen (our SC-BRIN Faculty Fellow) will be developing the project A: "Viral and Host Cell Determinants of Human Papillomavirus (HPV) Type 16 Integration and HPV-mediated Transformation". Dr. Randall Harris (hired in January 04) will be developing the project B: "Role of Biofilms in the Development of Colon Cancer." Both projects will be mentored by senior faculty at the South Carolina Cancer Center. To further develop our research enterprise we request support for a third pilot project maturing from an existing collaboration with the USC School of Medicine. Project C: ?Molecular Targets for Zinc in Prostate Cancer Prevention? will be led by Dr. Omar Bagasra, a senior faculty member at Claflin. 3) For Faculty, Postdoctoral and Staff Recruitment we are requesting a) Salary support and start-up packages for two newly approved tenure track faculty positions for a protein biochemist and a structural biochemist, b) support and training for two minority post-doctoral researchers, and c) support for a laboratory technicians for the SCCBT. Together, these three sets of activities are all designed to enhance the research programs of the SCCBT and will allow Claflin University faculty, students, and research staff to contribute substantially to the overall South Carolina INBRE theme of Developmental and Applied Bioengineering.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。克拉夫林大学位于南卡罗来纳州奥兰治堡，距南卡罗来纳大学 (USC) 仅 35 英里。克拉夫林大学是该州第一所设立生物技术中心（南卡罗来纳州生物技术中心或 SCCBT）并开设新的生物技术理学硕士 (MS) 课程的 HBCU。作为 SC-BRIN 的指导机构，克拉夫林建立了最先进的 DNA 测序设施。克拉夫林大学因加入 SC-BRIN 第一阶段而受益匪浅。我们的管理者（特别是我们的校长）致力于为整个机构制定一个研究计划，作为 SC-BRIN 的直接成果。我们已经通过 SC-BRIN 在南加州大学和克莱姆森大学的五名教职员工之间建立了合作联系，我们准备加强我们的研究事业，确保我们的计划将为 SC-INBRE 的整体成功做出贡献。该应用程序重点关注三个研究基础设施建设领域： 1) 对于学生培训，我们建议：为总共 15 名研究生 (MS) INBRE 研究员提供支持 b．支持总共 18 个学年的本科生研究实习 2) 对于教师发展，我们请求支持两个合作研究项目的开发，其中涉及克拉夫林聘用的两名新终身教授。陈建国博士（我们的 SC-BRIN 教员研究员）将开发项目 A：“人乳头瘤病毒 (HPV) 16 型整合和 HPV 介导的转化的病毒和宿主细胞决定因素”。 Randall Harris 博士（1 月 4 日聘用）将开发项目 B：“生物膜在结肠癌发展中的作用”。这两个项目都将由南卡罗来纳州癌症中心的高级教师指导。为了进一步发展我们的研究事业，我们请求对第三个试点项目的支持，该项目是与南加州大学医学院现有合作的成果。项目 C：“锌在前列腺癌预防中的分子靶点？”该项目将由 Claflin 高级教员 Omar Bagasra 博士领导。 3) 对于教师、博士后和工作人员招聘，我们要求 a) 为两个新批准的终身教授职位（一名蛋白质生物化学家和一名结构生物化学家）提供薪资支持和启动方案，b）为两名少数族裔博士后研究人员提供支持和培训，以及 c）为 SCCBT 的实验室技术人员提供支持。这三组活动旨在加强 SCCBT 的研究项目，并使克拉夫林大学的教师、学生和研究人员能够为南卡罗来纳州 INBRE 发展和应用生物工程的总体主题做出重大贡献。