INBRE: CLAFLIN U: FACULTY AND UNDERGRADUATE RESEARCH DEVELOPMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 克莱夫林大学位于南卡罗来纳州的奥兰治堡，距离南卡罗来纳大学(USC)仅35英里。克莱夫林大学是该州第一个成立生物技术中心(南卡罗来纳州生物技术中心或SCCBT)的HBCU，并设立了一个新的生物技术科学硕士(MS)项目。作为SC-Brin的指导机构，Claflin建立了最先进的DNA测序设施。克拉夫林大学因被纳入SC-BRIN的第一阶段而受益匪浅。我们的管理人员(特别是我们的总裁)致力于为整个机构开发一个研究计划，作为SC-BRIN的直接成果。我们已经通过SC-BRIN在南加州大学和克莱姆森大学的五名教职员工之间建立了合作关系，我们准备加强我们的研究事业，确保我们的项目将为SC-INBRE的全面成功做出贡献。本申请侧重于三个研究基础设施建设领域： 1)在学员培训方面，我们建议： A.总共支持15名研究生(MS)INBRE研究人员 B.共支持18个学年的本科生科研实习 2)对于教师发展，我们请求支持开发两个合作研究项目，涉及克拉夫林的两名新的终身教职跟踪教师。陈建国博士(我们的SC-Brin教研员)将开发项目A：“人乳头瘤病毒(HPV)16型整合和HPV介导的转化的病毒和宿主细胞决定因素”。兰德尔·哈里斯博士(于2004年1月受聘)将开发B项目：“生物膜在结肠癌发展中的作用”。这两个项目都将由南卡罗来纳州癌症中心的资深教员指导。为了进一步发展我们的研究事业，我们请求支持与南加州大学医学院现有的合作关系中成熟的第三个试点项目。项目C：“锌在前列腺癌预防中的分子靶标”，将由克拉夫林大学的高级教员奥马尔·巴斯格拉博士领导。 3)对于教师、博士后和工作人员的招聘，我们要求：a)为两个新批准的终身教职教师职位--一名蛋白质生物化学家和一名结构生物化学家--提供工资支持和启动方案；b)支持和培训两名少数民族博士后研究人员；以及c)支持SCCBT的实验室技术人员。总之，这三组活动都旨在加强SCCBT的研究计划，并将使克拉夫林大学的教职员工、学生和研究人员为整个南卡罗来纳州INBRE的开发和应用生物工程主题做出重大贡献。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Claflin University is located in Orangeburg, South Carolina, only 35 miles from the University of South Carolina (USC). Claflin University is the first HBCU in the state to start a Center for Biotechnology (The South Carolina Center for Biotechnology or SCCBT) as well as instituting a new Masters of Science (MS) program in Biotechnology. As a mentored institution of the SC-BRIN, Claflin established a state-of-the-art DNA sequencing facility. Claflin University benefited greatly by inclusion in the first phase of the SC-BRIN. Our administrators (in particular our President) are committed to developing a research program for the entire institution as a direct outcome of the SC-BRIN. We have already established collaborative links between five of our faculty and faculty at USC and Clemson University through the SC-BRIN and we are ready to step-up our research enterprise, assuring that our program will contribute to the overall success of the SC-INBRE. This application focuses on three research infrastructure building areas: 1) For Student Training, we propose: a. Support for a total of 15 graduate student (MS) INBRE Research Fellows b. Support for a total of 18 academic year undergraduate research internships 2) For Faculty Development, we request support for the development of two collaborative research projects involving two new tenure track faculty hires at Claflin. Dr. Jianguo Chen (our SC-BRIN Faculty Fellow) will be developing the project A: "Viral and Host Cell Determinants of Human Papillomavirus (HPV) Type 16 Integration and HPV-mediated Transformation". Dr. Randall Harris (hired in January 04) will be developing the project B: "Role of Biofilms in the Development of Colon Cancer." Both projects will be mentored by senior faculty at the South Carolina Cancer Center. To further develop our research enterprise, we request support for a third pilot project maturing from an existing collaboration with the USC School of Medicine. Project C: "Molecular Targets for Zinc in Prostate Cancer Prevention", will be led by Dr. Omar Bagasra, a senior faculty member at Claflin. 3) For Faculty, Postdoctoral, and Staff Recruitment we are requesting: a) Salary support and start-up packages for two newly approved tenure track faculty positions, a protein biochemist and a structural biochemist; b) support and training for two minority post-doctoral researchers; and c) support for laboratory technicians for the SCCBT. Together, these three sets of activities are all designed to enhance the research programs of the SCCBT and will allow Claflin University's faculty, students, and research staff to contribute substantially to the overall South Carolina INBRE theme of Developmental and Applied Bioengineering.