INBRE: CLAFLIN U: FACULTY AND UNDERGRADUATE RESEARCH DEVELOPMENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 克拉夫林大学位于南卡罗来纳州的奥兰治堡，距离南卡罗来纳州大学（USC）仅35英里。 克拉夫林大学是该州第一个开设生物技术中心（南卡罗来纳州生物技术中心或SCCBT）的HBCU，并开设了一个新的生物技术科学硕士（MS）课程。作为SC-BRIN的指导机构，克拉夫林建立了最先进的DNA测序设施。 克拉夫林大学因被列入SC-BRIN的第一阶段而受益匪浅。 我们的管理人员（特别是我们的总统）致力于为整个机构制定一项研究计划，作为SC-BRIN的直接成果。 我们已经通过SC-BRIN在南加州大学和克莱姆森大学的五名教师和教师之间建立了合作联系，我们准备加强我们的研究事业，确保我们的计划将有助于SC-INBRE的整体成功。 该应用程序侧重于三个研究基础设施建设领域： 1)对于学生培训，我们建议： a.支持总共15名研究生（MS）INBRE研究员 B.共支持18学年本科生研究实习 2)对于教师发展，我们要求支持两个合作研究项目的发展，涉及两个新的终身教职员工在克拉夫林雇用。 Jianguo Chen博士（我们的SC-BRIN教职研究员）将开发项目A：“人乳头瘤病毒（HPV）16型整合和HPV介导的转化的病毒和宿主细胞决定因素”。 兰德尔·哈里斯博士（2004年1月受聘）将开发项目B：“生物膜在结肠癌发展中的作用”。“这两个项目将由南卡罗来纳州癌症中心的高级教员指导。为了进一步发展我们的研究事业，我们请求支持第三个试点项目，该项目将从与南加州大学医学院的现有合作中成熟。 项目C：“锌在前列腺癌预防中的分子靶点”，将由克拉夫林的高级教员Omar Bagasra博士领导。 3)对于教师，博士后和工作人员招聘，我们要求：a）两个新批准的终身教职职位，蛋白质生物化学家和结构生物化学家的工资支持和启动包; B）支持和培训两个少数民族博士后研究人员;和c）支持SCCBT的实验室技术人员。总之，这三套活动都旨在加强SCCBT的研究计划，并将允许克拉夫林大学的教师，学生和研究人员作出重大贡献的整体南卡罗来纳州INBRE发展和应用生物工程的主题。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Claflin University is located in Orangeburg, South Carolina, only 35 miles from the University of South Carolina (USC). Claflin University is the first HBCU in the state to start a Center for Biotechnology (The South Carolina Center for Biotechnology or SCCBT) as well as instituting a new Masters of Science (MS) program in Biotechnology. As a mentored institution of the SC-BRIN, Claflin established a state-of-the-art DNA sequencing facility. Claflin University benefited greatly by inclusion in the first phase of the SC-BRIN. Our administrators (in particular our President) are committed to developing a research program for the entire institution as a direct outcome of the SC-BRIN. We have already established collaborative links between five of our faculty and faculty at USC and Clemson University through the SC-BRIN and we are ready to step-up our research enterprise, assuring that our program will contribute to the overall success of the SC-INBRE. This application focuses on three research infrastructure building areas: 1) For Student Training, we propose: a. Support for a total of 15 graduate student (MS) INBRE Research Fellows b. Support for a total of 18 academic year undergraduate research internships 2) For Faculty Development, we request support for the development of two collaborative research projects involving two new tenure track faculty hires at Claflin. Dr. Jianguo Chen (our SC-BRIN Faculty Fellow) will be developing the project A: "Viral and Host Cell Determinants of Human Papillomavirus (HPV) Type 16 Integration and HPV-mediated Transformation". Dr. Randall Harris (hired in January 04) will be developing the project B: "Role of Biofilms in the Development of Colon Cancer." Both projects will be mentored by senior faculty at the South Carolina Cancer Center. To further develop our research enterprise, we request support for a third pilot project maturing from an existing collaboration with the USC School of Medicine. Project C: "Molecular Targets for Zinc in Prostate Cancer Prevention", will be led by Dr. Omar Bagasra, a senior faculty member at Claflin. 3) For Faculty, Postdoctoral, and Staff Recruitment we are requesting: a) Salary support and start-up packages for two newly approved tenure track faculty positions, a protein biochemist and a structural biochemist; b) support and training for two minority post-doctoral researchers; and c) support for laboratory technicians for the SCCBT. Together, these three sets of activities are all designed to enhance the research programs of the SCCBT and will allow Claflin University's faculty, students, and research staff to contribute substantially to the overall South Carolina INBRE theme of Developmental and Applied Bioengineering.