TULANE COBRE: GENETIC POLYMORPHISMS IN EPOXYGENASE PATHWAY IN HYPERTENSION

TULANE COBRE：高血压环氧合酶途径的基因多态性

• 批准号: 7381799
• 负责人: ALBERT W DREISBACH
• 金额: $ 28.16万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381799
• 关键词: TULANE; COBRE; GENETIC; POLYMORPHISMS; EPOXYGENASE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For Project 4, Dreisbach tests the hypothesis that common genetic polymorphisms in both CYP (cytochrome) arachidonate pathways and the bradykinin receptors individually or in combination lead to altered levels of 20-HETE and EETs that play a mechanistic role in salt-sensitive and salt-resistant hypertension in humans.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。在项目4中，德赖斯巴赫检验了以下假设：细胞色素花生四烯酸途径和缓激肽受体的共同遗传多态性单独或联合导致20-HETE和Ehrs水平的改变，这在人类盐敏感性和盐抵抗性高血压中起机制作用。