KANSAS U COBRE: GENETIC MODELS OF CONGENITAL VASCULAR MALFORMATIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的工作是了解先天性血管畸形的起源。这些努力特别关注Klippel Trenaunay综合征的遗传基础，以及VG5Q基因在这种疾病中的作用。目前正在开发动物模型，以了解该因子的功能，并开发这种疾病的模型。该项目的期望是在分子水平上了解该基因产物如何发挥作用，以及它如何干扰胎儿血管的正常发育。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The work in the project is to develop an understanding of the origins of congenital vascular malformations. These efforts are specifically looking at the genetic basis of Klippel Trenaunay Syndrome, and the role of the gene VG5Q in this disease. Animal models are being developed to understand the functions of this factor, as well as to develop a model of this disease. The expections of this project are to understand, at a molecular level, how this gene product functions and how it interferes with normal development of the fetal vasculature.