GENETIC POLYMORPHISMS AND PREECLAMPSIA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Minority groups are clearly under-represented within biomedical fields. Our hypothesis is that direct involvement of tribal college students in an ongoing, locally focused, biomedical research effort will increase student interest in and understanding of biomedical sciences. Preeclampsia/eclampsia (P/E) is a common complication of pregnancy that has serious maternal and fetal consequences. We propose investigation of the prevalence and relationship of genetic risk factors to P/E in an American Indian (AI) population who are at high risk to develop P/E. Methods: A case-control study (target enrollment: 67 cases) will assess the relationship between genetic polymorphisms and the development of preeclampsia. Supervised students in the laboratory, established at the Turtle Mountain Community College, will conduct all genotyping. Initial training has focused on research ethics, and is provided by the principal investigator (PI) and a nationally recognized, online website. Approvals have been obtained from the tribal government and all relevant IRBs. Results: The research ethics training has educated and sensitized those involved about the importance of the informed consent process and the critical obligations of investigators. A total of 37 participants have been enrolled during the first 4 months of active enrollment. Students have conducted training sessions for fellow students and successfully designed a logo, an informational pamphlet and poster. Training has also been completed on genetic analysis techniques, lab safety, universal precautions, HIPPA, and Privacy Act. A field trip to various genetic laboratories and the Community Health Department in Winnipeg, Manitoba allowed the students to see direct application of genetic principles to health problems. Students also visited the University of North Dakota and saw ongoing animal-model research in preeclampsia. Conclusions: It is premature to offer conclusions; but our hope is that this research study will interest and educate both students and community members about research and biomedical fields in general.