CARDIOVASCULAR DISEASE IN SIOUX INDIANS

强心脏研究是一项关于美国印第安人心血管疾病（CVD）的研究，涉及亚利桑那州、俄克拉荷马州、北达科他州和南达科他州的13个印第安社区。第一阶段于1988年10月1日开始，包括一项医学回顾，以确定1984年至1988年间45至74岁人群的心血管疾病死亡率和发病率。在达科他中心，对奥格拉哈苏族、夏延河苏族和灵湖部落的1522名成员进行了体检，以测量心血管和外周血管疾病的患病率，以及已知和可疑的风险因素。1993-1995年和1997-1999年对该队列中幸存的成员进行了随访检查（第二期和第三期）。此外，9个家庭（包括258名研究参与者的亲属）和68名原始队列参与者（共326人）被纳入与心血管疾病及其危险因素相关的遗传因素的试点家庭研究。本申请提出了达科他州强心脏研究的扩展（第四阶段），目的是在第三阶段检查的家庭成员，重新检查326名家庭成员，并检查另外30个家庭的900名家庭成员。对1226名家族成员的检查将包括心脏和颈动脉超声研究、心电图、应用血压计、血液化学、血脂和DNA。扩大家庭研究将允许对心血管疾病的遗传决定因素进行完整的调查。

The Strong Heart Study, a study of cardiovascular disease (CVD) among American Indians, involves 13 Indian communities in Arizona, Oklahoma and North and South Dakota. Phase I, which began on October 1, 1988 included a medical review to determine mortality and morbidity for CVD in individuals age 45 to 74 years old between 1984 to 1988. In the Dakota Center, a physical examination was performed on 1522 members of the Oglaha Sioux, Cheyenne River Sioux and Spirit Lake Tribes, to measure prevalence and cardiovascular and peripheral vascular disease, and known and suspected risk factors. Follow up exams (Phase II and Phase III) were conducted on surviving embers of this cohort from 1993-1995 and 1997-1999. In addition, nine families that included 258 relatives of study participants and 68 of the original cohort participants (326 total) were included in the pilot Family Study of genetic factors related to CVD and its risk factors. This application proposes an extension (Phase IV) of the Strong Heart Study in the Dakotas The aims of family members examined in Phase III, to re-examine those 326 family members and to examine an additional 900 family members in 30 more families. The examination of the 1226 family members will include cardiac and carotid ultrasound studies, EKGs, applination tonometry, blood chemistries and lipids and DNA. Expanding the family study will allow complete investigation of genetic determinants of CVD.