Factors Influencing Pediatric Asthma into Adulthood (FIPA2)

标题：FIPA2 M-PI：BEST/Erdei/Torgerson 项目摘要 北部平原地区美洲印第安人(AI)社区的儿童哮喘呈现严重的 健康差距。虽然之前在少数族裔社区进行的许多工作-但不是在人工智能儿童中-看起来 在个人层面对儿童哮喘的影响，并让父母对哮喘控制负责，我们的 研究将带来一个更全面和现实的框架。我们的新方法将推动 从收集的数据中研究部落卫生政策的变化。FIPA2研究旨在利用 先前NIMHD资助的影响儿童哮喘的因素研究(U54MD008164)，成功 2013-2017年招收了324名夏延河苏族部落(CRST)儿童(6-17岁)。这项研究还发现 一项随机教育临床试验部分(NCT 03302962)，我们记录了这项工作的结果。在……里面 在FIPA2研究中，我们将研究社会、环境和免疫之间的复杂相互作用 对病毒性呼吸道感染的反应在很大程度上仍不为人所知的知识差距。在这个持续的人工智能中 以社区为重点的儿童哮喘研究，我们将检验AI哮喘儿童有 与非病毒性呼吸道感染相比，几种病毒性呼吸道感染的免疫应答变化 哮喘。我们还将调查社会和环境因素(SEF)是否对此有显著影响 通过应激诱导的免疫状态的改变而产生的差异。我们将探索病毒呼吸道的作用 感染(呼吸道合胞病毒、鼻病毒C以及甲型和乙型流感)和SEF对哮喘严重程度的影响，包括 病情恶化、急诊室就诊/住院以及哮喘药物的使用。目标1将确定社交和 影响哮喘易感性、严重程度和长期呼吸道健康的环境因素(SEF)。 参与者将在我们的密苏里州Break工业研究公司总部注册，方法是 保留社区。为了实现招生目标，我们还将在南卡罗来纳州的拉皮特城注册，这是一个城市环境 人工智能也位于那里(占该市人口的12.4%)。在目标2中，我们将研究环境保护基金在以下方面的角色 感染和不感染AI儿童对病毒性呼吸道感染的免疫学和临床反应 哮喘。我们将检验我们的假设，即与SEF的详细调查措施和免疫学的相互作用 和VRIs的临床结果，包括患有和不患有哮喘的参与者病毒反应的季节性 是我们人工智能参与者中最强大和最重要的预测因素。目标3将带来全面和 社区对这项研究的生动意见，并将受益于我们当地的社区咨询委员会(CAB)， 支持这项研究。我们将依靠自己经验丰富的基于CBPR的双向流程评估。 我们将创建一个可行的、社区驱动的哮喘预防框架，该框架将是有效的，并且可以 也适用于其他人工智能社区。

Title: FIPA2 M-PI: Best/Erdei/Torgerson Project Summary Pediatric asthma in American Indian (AI) communities of the Northern Plains Region presents a serious health disparity. While many previous works carried out in minority communities – but not in AI children- looked at individual level of influences on pediatric asthma and made parents responsible for asthma control, our study will bring together a more comprehensive and realistic framework. Our novel approach will move the study from the collected data toward Tribal health policy change. The FIPA2 study is designed to leverage the previously NIMHD-funded Factors Influencing Pediatric Asthma study (U54MD008164) which successfully enrolled 324 Cheyenne River Sioux Tribal (CRST) children (age 6-17 years) in 2013-2017. That study also had a randomized educational clinical trial component (NCT 03302962) and we documented results of that work. In the FIPA2 study, we will examine the complex interplay between social, environmental and immunological response to viral respiratory infections an gap in knowledge that remains largely unknown. In this continued AI community-focused pediatric asthma study, we will test the hypothesis that AI children with asthma have alterations in immunological response to several viral respiratory infections as compared to those without asthma. We will also investigate whether social and environmental factors (SEF) significantly contribute to this disparity through stressed-induced modification of immune state. We will explore the role of viral respiratory infections (RSV, rhinovirus C, and influenza A and B) and SEF on asthma severity, including frequency of exacerbations, ER visits/hospitalizations, and use of asthma medications. Aim 1 will identify social and environmental factors (SEF) that contribute to asthma susceptibility, severity and long-term respiratory health. Participants will be enrolled at our Missouri Breaks Industries Research Inc. main office by working with Reservation communities. To achieve enrollment goals, we will also enroll in Rapid City, SD, an urban setting where AIs also located (12.4% of the city’s population). In Aim 2, we will examine the role of SEF on immunological and clinical response to viral respiratory infections (VRIs) in AI children with and without asthma. We will test our hypothesis that interactions with detailed survey measures of SEF with immunological and clinical outcomes of VRIs, including seasonality of viral responses in participants with and without asthma are the strongest and most significant predictors in our AI participants. Aim 3 will bring a comprehensive and vivid community input to this study and will benefit from our local community advisory board (CAB) that supports the study. We will rely on our own, experienced CBPR-based and bidirectional process evaluation. We will create a feasible and community-driven asthma prevention framework that will be effective and can be applied in other AI communities as well.