MS INBRE: BIOINFORMATICS CORE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。MFGN生物信息学核心(BC)为密西西比州的科学家和学生提供三项主要服务。第一个是一套可通过网络访问的序列分析工具。EMBOSS(欧洲分子生物学开放软件套件)允许我们的客户从该州的任何地方访问该软件，在MFGN服务器上分析和存储序列数据。该核心提供的第二项主要服务是微阵列数据分析。这些努力包括对微阵列数据的统计分析和管理，对基因组、蛋白质组和代谢组数据的分析，以及生物信息学工具的开发。核心提供的第三项服务是生物数据库设计。通过招募计算生物学家邓友平博士担任终身教职，这些努力成为可能。邓博士是生物信息学专家，并担任MFGN生物信息学核心的副主任。目前正在利用生物信息学核心设施和专门知识开展11个以上的项目。另一个正在进行的核心项目是在公共投资机构安装接入电网节点(AGN)。核心是使用NCRR授予的补充来增加PUI的带宽，这对使活动星系核上线至关重要。所有PUI还将配备Internet2，这将使他们能够充分参与MFGN的联网和指导活动。由于卡特里娜飓风，这些努力被暂时推迟。BellSouth(互联网服务提供商)和相关校园(USM和PUIS)的IT人员需要时间修复飓风造成的破坏，然后才能继续项目工作。我们很高兴地报告，Internet2升级工作已重回正轨。所有必要的硬件都已订购完毕，所有相关IT部门都已敲定并批准了计划。我们预计该项目将于2006年3月完成。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The MFGN bioinformatics core (BC) provides three major services to Mississippi scientists and students. The first one is a web-accessible suite of sequence analysis tools. EMBOSS (European Molecular Biology Open Software Suite) allows our clients to access the software from anywhere in the state, analyze and store sequence data on MFGN servers. The second major service offered by the core is microarray data analysis. These efforts include statistical analysis and management of microarray data, analysis of genomic, proteomic and metabolomic data, and development of bioinformatics tools. The third service offered by the core is biological database design. These efforts have been made possible by the recruitment of a computational biologist, Dr. Youping Deng, into a tenure track position. Dr. Deng is an expert in bioinformatics and acts as associate director of the MFGN bioinformatics core. More than eleven projects are currently underway utilizing the bioinformatics core facilities and expertise. Another ongoing project at the core is the installation of access grid nodes (AGNs) at the PUI institutions. The core is using the supplement awarded by NCRR to increase bandwidth at the PUIs, which is essential for bringing the AGNs on-line. All PUIs will also be provided with Internet2, which will allow them to fully participate in the networking and mentoring activities of MFGN. These efforts were temporarily delayed due to Hurricane Katrina. Bellsouth (internet service provider) and IT personnel at the campuses involved (USM and PUIs) needed time to repair damage caused by the hurricane before continuing work on the project. We are pleased to report that work on the Internet2 upgrade is back on track. All the necessary hardware has been ordered, and plans are finalized and approved by all of the IT departments involved. We expect the project to be completed by March 2006.