EFFECT OF PIOGLITAZONE ON OVARIAN GENE EXPRESSION IN LETHAL YELLOW MOUSE

吡格列酮对致死性黄鼠卵巢基因表达的影响

• 批准号: 7381697
• 负责人: MAUREEN R DIGGINS-HUTCHESON
• 金额: $ 0.22万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381697
• 关键词: EFFECT; PIOGLITAZONE; OVARIAN; GENE; EXPRESSION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mice possessing the lethal yellow mutation (C57BL/6J) become obese and develop hyperleptinemia as they age. Fertility declines with developing obesity and leptin resistance. The goal is to determine the relationship between altered leptin physiology and decreased reproductive function in these mice. Declining fertility appears to be related to excessive levels of serum leptin and development of leptin resistance. The cellular mechanisms by which this occurs are the focus of the study.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。拥有致命黄色突变（C57 BL/6 J）的小鼠随着年龄的增长变得肥胖并发展为高瘦素血症。随着肥胖和瘦素抵抗的发展，生育能力下降。目的是确定这些小鼠中瘦素生理学改变和生殖功能下降之间的关系。生育能力下降似乎与血清瘦素水平过高和瘦素抵抗的发展有关。这种情况发生的细胞机制是研究的重点。