OBESITY, LEPTIN RESISTANCE AND OVARIAN FUNCTION IN MICE

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。在他们关于体脂和生育能力的研究中，实验室使用了一种叫做致命黄鼠的突变小鼠。该基因位于2号染色体上的刺鼠基因座，在纯合条件下具有致命性。杂合子小鼠存活，但具有称为致死性黄色综合征（LYS）的表型。LYS包括黄色毛色，成年肥胖症，生育能力下降显然与体脂增加有关。目前，该实验室正在研究在低脂肪和高脂肪饮食中饲养的小鼠的怀孕成功率，以研究饮食如何改变基因的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For their research on body fat and fertility, the lab uses a mouse mutant called the lethal yellow mouse. The gene, found at the agouti locus on chromosome 2, is lethal in the homozygous condition. Heterozygous mice live but have a phenotype called the lethal yellow syndrome (LYS). The LYS includes yellow coat color, adult onset obesity, and decreasing fertility apparently linked with increasing body fat. Currently the lab is studying the pregnancy success in mice raised on diets with low versus high fat content in order to examine how diet may modify the effects of the gene.