OBESITY, LEPTIN RESISTANCE AND OVARIAN FUNCTION IN MICE

小鼠肥胖、瘦素抵抗和卵巢功能

• 批准号: 7381694
• 负责人: MAUREEN R DIGGINS-HUTCHESON
• 金额: $ 6.16万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381694
• 关键词: OBESITY; LEPTIN; RESISTANCE; OVARIAN; FUNCTION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For their research on body fat and fertility, the lab uses a mouse mutant called the lethal yellow mouse. The gene, found at the agouti locus on chromosome 2, is lethal in the homozygous condition. Heterozygous mice live but have a phenotype called the lethal yellow syndrome (LYS). The LYS includes yellow coat color, adult onset obesity, and decreasing fertility apparently linked with increasing body fat. Currently the lab is studying the pregnancy success in mice raised on diets with low versus high fat content in order to examine how diet may modify the effects of the gene.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。在他们对身体脂肪和生育能力的研究中，该实验室使用了一种名为致命黄色小鼠的小鼠突变体。该基因位于2号染色体上的刺鼠基因，在纯合子条件下是致命的。杂合子小鼠存活下来，但有一种被称为致死性黄色综合症(LYS)的表型。Lys包括黄色的毛色、成年后的肥胖以及生育力下降，显然与身体脂肪的增加有关。目前，该实验室正在研究低脂肪饮食和高脂肪饮食饲养的小鼠的怀孕成功，以检查饮食可能如何改变该基因的影响。