OBESITY, DECREASED FERTILITY, AND LEPTIN RESISTANCE IN THE LETHAL YELLOW MOUSE

致命黄鼠的肥胖、生育能力下降和瘦素抵抗

• 批准号: 7720215
• 负责人: MAUREEN R DIGGINS-HUTCHESON
• 金额: $ 8.61万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720215
• 关键词: Adverse effects; Computer Retrieval of Information on Scientific Projects Database; Development; Embryo; Fertility; Funding; Goals; Grant; Hormones; Human; Institution; Leptin; Leptin resistance; Mammals; Mus; Obesity; Oocytes; Ovarian; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; Work; mouse model; oocyte maturation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of our research is to understand the relationship between increasing obesity and decreasing fertility in humans and other mammals using the lethal yellow mouse model. We are currently working on the role of the hormone leptin in ovarian function and oocyte development and the adverse effects of leptin resistance on follicle development, oocyte maturation, and embryo viability.

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