MISSISSIPPI COBRE: CORE B: CHEMISTRY CORE

密西西比 COBRE：核心 B：化学核心

• 批准号: 7382242
• 负责人: JORDAN K ZJAWIONY
• 金额: $ 23.28万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-04 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7382242
• 关键词: Fungi; aquatic organism; bacteria; biological products; lead; nervous system; plants; psychotropic drugs; role; saltwater environment

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objectives: The major aims of the Chemistry Core of the Center of Research Excellence in Natural Products Neuroscience are to isolate, characterize and optimize the active principles of plants, bacteria, fungi, and marine organisms with potential nervous system activity. This core will be responsible for the elucidation of structures and provide material for in vitro and in vivo pharmacological studies in order to develop new psychotropic drug candidates and research tools to study nervous system function. The Chemistry Core will also have an advisory role for individual projects that require expertise in the isolation, structure elucidation and lead optimization of natural products based drug leads and prototypes. The expertise of the Chemistry Core includes: (a) isolation and purification of active secondary metabolites on a mg to kg scale, (b) structure elucidation of isolated active principles, (c) re-isolation or synthesis of larger quantities of active components for in vitro and in vivo studies, and (d) semi-synthetic modification of lead compounds to generate SAR data and to further develop drug candidates.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。目的：天然产物神经科学卓越研究中心化学核心的主要目标是分离、表征和优化具有潜在神经系统活性的植物、细菌、真菌和海洋生物的活性成分。该核心将负责阐明结构，并为体外和体内药理学研究提供材料，以开发新的精神药物候选药物和研究工具，以研究神经系统功能。化学核心还将为需要以天然产品为基础的药物先导和原型的分离、结构阐明和先导优化方面的专业知识的个别项目提供咨询。化学核心的专长包括：(A)从毫克到千克的活性次生代谢物的分离和纯化；(B)分离的活性成分的结构阐明；(C)重新分离或合成更多的活性成分，用于体外和体内研究；以及(D)对先导化合物进行半合成修饰，以产生SAR数据并进一步开发候选药物。