MISSISSIPPI COBRE: CORE B: CHEMISTRY CORE

密西西比 COBRE：核心 B：化学核心

• 批准号: 7610762
• 负责人: JORDAN K ZJAWIONY
• 金额: $ 18.2万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7610762
• 关键词: Applications Grants; Biological Factors; Centers of Research Excellence; Chemicals; Chemistry; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Faculty; Funding; Grant; In Vitro; Individual; Institution; Lead; Mississippi; Modification; Neurosciences; Organism; Pharmaceutical Preparations; Play; Psychotropic Drugs; Research; Research Personnel; Resources; Role; Source; Structure; United States National Institutes of Health; Universities; in vivo; marine organism; plant fungi

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The major aims of the Chemical Core of the Center of Research Excellence in Natural Products Neuroscience are to support the development and submission of RO1/R21 grant applications by Junior Faculty from the University of Mississippi. The Core provides expertise for the isolation the active principles from selected plants, fungi, and marine organisms with CNS activity, elucidate their structures and provide material for in vitro and in vivo pharmacological studies in order to develop new psychotropic drug candidates. The chemical core also plays an advisory role for individual projects that require expertise in isolation and structure elucidation of secondary metabolites from selected organisms. The specific aims for the chemical core as part of their support actvities include: (a) isolation of active secondary metabolites from organisms with CNS activities. (b) structure elucidation of isolated active principles (c) re-isolation or synthesis of 100mg-1g quantities of active components for in vitro and in vivo studies. (d) semi-synthetic modification of lead compounds to generate SAR data and to develop drug candidates.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 天然产物神经科学卓越研究中心化学核心的主要目标是支持密西西比大学初级学院开发和提交RO1/R21拨款申请。该中心为从具有中枢神经系统活性的植物、真菌和海洋生物中分离有效成分提供专业知识，阐明其结构，并为体外和体内药理研究提供材料，以开发新的精神药物候选药物。化学核心还为个别项目发挥咨询作用，这些项目需要从选定生物中分离和结构阐明次生代谢物方面的专业知识。作为其支助活动一部分的化学核心的具体目标包括： (A)从具有中枢神经系统活性的生物体中分离活性次生代谢物。 (B)分离活性成分的结构说明 (C)重新分离或合成100 mg-1g量的活性成分，用于体外和体内研究。 (D)对先导化合物进行半合成修饰，以产生搜索结果数据和开发候选药物。