PLANNING INTERDISCIPLINARY STUDIES OF DIABETIC HEART: FUNDAMENTAL DISCOVERY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。规划过程将遵循与糖尿病心肌和血管疾病的不同组成部分相关的两条基本发现路径：新陈代谢(代谢综合征和心力衰竭)和炎症/凝血(血管疾病)。这些研究途径将作为发现和识别与早期发现心血管疾病或对患有显性疾病的个体进行风险分层相关的潜在生物标记物的产卵场所。1.基本发现途径1--新陈代谢(代谢综合征、心力衰竭)代谢途径计划小组的总体目标是开发跨学科的方法来确定糖尿病心脏从小鼠到人类的代谢重塑的发病机制。以下五个研究学科及其各自的代表将组成代谢途径规划小组的初始成员：中间代谢、发育和分子生物学、遗传学、信号转导和小鼠生理学和成像。2.基本发现途径2--炎症/凝血(血管疾病)。炎症凝血途径规划小组的目标是制定策略，以确定动脉粥样硬化的发病机制和脆弱的动脉粥样硬化斑块。将特别关注胰岛素抵抗和糖尿病状态之间的影响之间的相互作用。第二个主要目标是开发一种检测和表征血管斑块的方法。以下四个研究学科及其各自的代表将包括炎症/凝血途径规划小组的初始成员：凝血生物学、炎症生物学、细胞外基质生物学和血管生理学

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The planning process will follow two Fundamental Discovery Pathways linked to distinct components of diabetic myocardial and vascular disease: Metabolism (Metabolic Syndrome and Heart Failure), and Inflammation/Coagulation (Vascular Disease). The research pathways will serve as the spawning ground for discovery and the identification of potential biomarkers relevant to early detection of cardiovascular disease or risk-stratification of the individual with overt disease. 1. Fundamental Discovery Pathway 1 - Metabolism (Metabolic Syndrome, Heart Failure). The overall goal of the Metabolism Pathway planning group is to develop interdisciplinary approaches to define the pathogenesis of metabolic remodeling of the diabetic heart from mouse to human. The following five research disciplines and their respective representatives will comprise the initial membership of the Metabolism Pathway planning group: Intermediary Metabolism, Developmental and Molecular Biology, Genetics, Signal Transduction, and Murine Physiology and Imaging. 2. Fundamental Diseovery Pathway 2 -Inflammation/Coagulation (Vascular Disease). The goal of the Inflammation Coagulation Pathway planning group is to develop strategies to define the pathogenesis of atherosclerosis and the vulnerable atherosclerotic plaque. Particular interest will be given to the interaction between the influence of the insulin resistant and diabetic states. A second major goal is to develop a means of detecting and characterizing vascular plaque. The following four research disciplines and their respective representatives will comprise the initial membership of the Inflammation/Coagulation Pathway planning group: Coagulation Biology, Inflammation Biology, Extracellular Matrix Biology, and Vascular Physiolog