PLANNING INTERDISCIPLINARY STUDIES OF DIABETIC HEART: FUNDAMENTAL DISCOVERY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。计划过程将遵循与糖尿病心肌和血管疾病的不同组成部分相关的两个基本发现途径：代谢（代谢综合征和心力衰竭）和炎症/凝血（血管疾病）。研究途径将作为发现和鉴定与心血管疾病早期检测或明显疾病个体风险分层相关的潜在生物标志物的温床。1.基础发现途径1 -代谢（代谢综合征，心力衰竭）。代谢途径计划组的总体目标是开发跨学科的方法来定义从小鼠到人类的糖尿病心脏代谢重塑的发病机制。以下五个研究学科及其各自的代表将组成代谢途径规划组的初始成员：中间代谢，发育和分子生物学，遗传学，信号转导和小鼠生理学和成像。 2.基本转移途径2 -炎症/凝血（血管疾病）。炎症凝血途径计划组的目标是制定策略，以确定动脉粥样硬化和易损斑块的发病机制。特别感兴趣的将是胰岛素抵抗和糖尿病状态的影响之间的相互作用。第二个主要目标是开发一种检测和表征血管斑块的方法。以下四个研究学科及其各自的代表将组成炎症/凝血途径规划组的初始成员：凝血生物学，炎症生物学，细胞外基质生物学和血管生理学

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The planning process will follow two Fundamental Discovery Pathways linked to distinct components of diabetic myocardial and vascular disease: Metabolism (Metabolic Syndrome and Heart Failure), and Inflammation/Coagulation (Vascular Disease). The research pathways will serve as the spawning ground for discovery and the identification of potential biomarkers relevant to early detection of cardiovascular disease or risk-stratification of the individual with overt disease. 1. Fundamental Discovery Pathway 1 - Metabolism (Metabolic Syndrome, Heart Failure). The overall goal of the Metabolism Pathway planning group is to develop interdisciplinary approaches to define the pathogenesis of metabolic remodeling of the diabetic heart from mouse to human. The following five research disciplines and their respective representatives will comprise the initial membership of the Metabolism Pathway planning group: Intermediary Metabolism, Developmental and Molecular Biology, Genetics, Signal Transduction, and Murine Physiology and Imaging. 2. Fundamental Diseovery Pathway 2 -Inflammation/Coagulation (Vascular Disease). The goal of the Inflammation Coagulation Pathway planning group is to develop strategies to define the pathogenesis of atherosclerosis and the vulnerable atherosclerotic plaque. Particular interest will be given to the interaction between the influence of the insulin resistant and diabetic states. A second major goal is to develop a means of detecting and characterizing vascular plaque. The following four research disciplines and their respective representatives will comprise the initial membership of the Inflammation/Coagulation Pathway planning group: Coagulation Biology, Inflammation Biology, Extracellular Matrix Biology, and Vascular Physiolog