PLANNING INTERDISCIPLINARY STUDIES OF DIABETIC HEART: FUNDAMENTAL DISCOVERY

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The planning process will follow two Fundamental Discovery Pathways linked to distinct components of diabetic myocardial and vascular disease: Metabolism (Metabolic Syndrome and Heart Failure), and Inflammation/Coagulation (Vascular Disease). The research pathways will serve as the spawning ground for discovery and the identification of potential biomarkers relevant to early detection of cardiovascular disease or risk-stratification of the individual with overt disease. 1. Fundamental Discovery Pathway 1 - Metabolism (Metabolic Syndrome, Heart Failure). The overall goal of the Metabolism Pathway planning group is to develop interdisciplinary approaches to define the pathogenesis of metabolic remodeling of the diabetic heart from mouse to human. The following five research disciplines and their respective representatives will comprise the initial membership of the Metabolism Pathway planning group: Intermediary Metabolism, Developmental and Molecular Biology, Genetics, Signal Transduction, and Murine Physiology and Imaging. 2. Fundamental Diseovery Pathway 2 -Inflammation/Coagulation (Vascular Disease). The goal of the Inflammation Coagulation Pathway planning group is to develop strategies to define the pathogenesis of atherosclerosis and the vulnerable atherosclerotic plaque. Particular interest will be given to the interaction between the influence of the insulin resistant and diabetic states. A second major goal is to develop a means of detecting and characterizing vascular plaque. The following four research disciplines and their respective representatives will comprise the initial membership of the Inflammation/Coagulation Pathway planning group: Coagulation Biology, Inflammation Biology, Extracellular Matrix Biology, and Vascular Physiolog