COBRE: U KS: P1: ID OF HSP90 COCHAPERONES, IMMUNOPHILINS & PROTEINS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。HSP90分子伴侣负责线状多肽的构象成熟，形成具有活性的三维酶和受体。依赖于Hsp90蛋白折叠机制的蛋白质的例子包括类固醇激素受体、Src激酶、HER-2激酶、Raf、p185、突变型p53、端粒酶、PKR、端粒酶、一氧化氮合酶、CDK-4和CDK-6等等。随着Hsp90继续演变为癌症治疗的流行靶点，需要更多的信息来验证其在关键调控蛋白成熟过程中的作用。例如，目前尚不清楚有多少客户蛋白需要Hsp90来折叠，也不知道Hsp90的四种已知形式(a、b、GRP94或Trp)、免疫亲和素(FKBP51、FKBP52或Cyp40)或辅伴侣中的哪一种参与了各种单独客户蛋白的折叠。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hsp90 molecular chaperones are responsible for the conformational maturation of linear peptides into active three-dimensional enzymes and receptors. Examples of proteins dependent on the Hsp90 protein folding machinery include steroid hormone receptors, Src kinase, Her-2 kinase, Raf, p185, mutant p53, telomerase, PKR, telomerase, nitric oxide synthase, CDK-4 and CDK-6 to name a few. As Hsp90 continues to evolve into a popular target for the treatment of cancer more information is required to validate its role in the maturation of key regulatory proteins. For example, it is not known how many client proteins require Hsp90 for folding, or which of the four known forms of Hsp90 (a, b, GRP94, or TRP), immunophilin (FKBP51, FKBP52, or Cyp40), or cochaperone participate in the folding of various individual client proteins.