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Diagnosis and Therapy of Drug and Chemical Toxicity(RMI)

药物和化学毒性的诊断和治疗（RMI）

基本信息

批准号：
7086284
负责人：
BRIJ Mohan MOUDGIL
金额：
$ 53.85万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-22 至 2008-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7086284
关键词：
NIH Roadmap Initiative tag bioengineering /biomedical engineering diagnosis design /evaluation diagnosis quality /standard drug adverse effect experimental designs health science research analysis /evaluation health science research support interdisciplinary collaboration rapid diagnosis therapy design /development toxicology

项目摘要

DESCRIPTION (provided by applicant): The diagnosis and therapy of drug and chemical toxicity is a significant public health problem and impacts millions of Americans with medical expenditures >$3 billion/year. This intractable public health threat remains for several reasons including a diverse number of toxic agents in multiple locations and patient classes, barriers to interdisciplinary research at the college and university level, and mechanisms of federal research support limited to single-investigator, hypothesis-driven, organ- or disease-specific studies. This proposal's overall objective is to develop interdisciplinary research teams to address this intractable public health threat using art adapted engineered systems method of research advocated by the National Science Foundation. To our knowledge this paradigm of physical research has not heretofore been applied to these types of biomedical problems. This objective will be achieved by accomplishing the following specific aims: Specific Aim 1. Create a planning structure through which individuals from a variety of relevant disciplines can interact, research strategies can be developed, and institutional barriers to collaborative research can be addressed. Specific Aim 2. Identify and minimize institutional barriers to interdisciplinary collaboration. Specific Aim 3. Identify specific problems in the diagnosis and treatment of toxicity and develop research strategies to solve them. Specific Aim 4. Conduct pilot research to test the feasibility of selected research strategies identified in Aim 3 and to validate the planning approach. A secondary objective of this project is to cause evolution at the University of Florida with respect to the financial, scientific, and other barriers to interdisciplinary research by employing management, administrative, and psychological teams. Successful achievement of this objective will enable additional activities similar to those described herein in order to advance the public health of the citizens of this nation not only for drug and chemical intoxication, but also for other seemingly intractable health problems.

描述（由申请人提供）：药物和化学品毒性的诊断和治疗是一个重大的公共卫生问题，影响着数百万美国人，每年的医疗支出超过30亿美元。这一棘手的公共卫生威胁仍然存在的原因有几个，包括不同数量的有毒物质在多个地点和病人类，在学院和大学水平的跨学科研究的障碍，以及联邦研究支持的机制限于单一的研究者，假设驱动，器官或疾病的具体研究。该提案的总体目标是发展跨学科研究团队，使用美国国家科学基金会倡导的艺术适应工程系统研究方法来解决这一棘手的公共卫生威胁。据我们所知，这种物理研究的范式迄今尚未应用于这些类型的生物医学问题。将通过实现以下具体目标来实现这一目标：具体目标1.创建一个规划结构，通过该结构，来自各种相关学科的个人可以进行互动，可以制定研究策略，并解决合作研究的制度障碍。具体目标2。识别并尽量减少跨学科合作的制度障碍。具体目标3。确定在诊断和治疗毒性的具体问题，并制定研究策略来解决这些问题。具体目标4。进行先导研究，以测试目标3所确定的选定研究策略的可行性，并验证规划方法。该项目的第二个目标是通过雇用管理，行政和心理团队，在佛罗里达大学促进跨学科研究的财务，科学和其他障碍的发展。这一目标的成功实现将使更多的活动类似于本文所述的，以促进这个国家的公民的公共健康，不仅对毒品和化学品中毒，而且对其他看似棘手的健康问题。