DIAGNOSIS AND THERAPY OF DRUG AND CHEMICAL TOXICITY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。描述(申请人提供)：药物和化学中毒的诊断和治疗是一个重大的公共卫生问题，每年影响数百万美国人的医疗支出&GT；30亿美元。这一棘手的公共卫生威胁仍然存在，原因有几个，包括多个地点和患者类别中存在多种有毒物质，学院和大学层面的跨学科研究面临障碍，以及联邦研究支持机制仅限于单一调查者、假设驱动、器官或疾病特定研究。S这项建议的总体目标是发展跨学科的研究团队，利用国家科学基金倡导的ART适应工程系统的研究方法来解决这一棘手的公共卫生威胁。据我们所知，到目前为止，这种物理研究的范例还没有被应用于这些类型的生物医学问题。这一目标将通过实现以下具体目标来实现：具体目标1.创建一种规划结构，通过该结构，来自不同相关学科的个人可以进行互动，可以制定研究战略，并可以解决合作研究的体制障碍。具体目标2.确定并最大限度地减少跨学科合作的体制障碍。具体目标3.确定在诊断和治疗毒性方面的具体问题，并制定解决这些问题的研究战略。具体目标4.开展试点研究，以测试目标3中确定的选定研究战略的可行性，并验证规划方法。这个项目的次要目标是通过雇佣管理、行政和心理团队，在佛罗里达大学推动跨学科研究的财务、科学和其他障碍的演变。这一目标的成功实现将使更多类似于本文所述的活动成为可能，以促进我国公民的公共健康，不仅是针对毒品和化学品中毒，而且是针对其他看似难以解决的健康问题。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The diagnosis and therapy of drug and chemical toxicity is a significant public health problem and impacts millions of Americans with medical expenditures >$3 billion/year. This intractable public health threat remains for several reasons including a diverse number of toxic agents in multiple locations and patient classes, barriers to interdisciplinary research at the college and university level, and mechanisms of federal research support limited to single-investigator, hypothesis-driven, organ- or disease-specific studies. This proposal''s overall objective is to develop interdisciplinary research teams to address this intractable public health threat using art adapted engineered systems method of research advocated by the National Science Foundation. To our knowledge this paradigm of physical research has not heretofore been applied to these types of biomedical problems. This objective will be achieved by accomplishing the following specific aims: Specific Aim 1. Create a planning structure through which individuals from a variety of relevant disciplines can interact, research strategies can be developed, and institutional barriers to collaborative research can be addressed. Specific Aim 2. Identify and minimize institutional barriers to interdisciplinary collaboration. Specific Aim 3. Identify specific problems in the diagnosis and treatment of toxicity and develop research strategies to solve them. Specific Aim 4. Conduct pilot research to test the feasibility of selected research strategies identified in Aim 3 and to validate the planning approach. A secondary objective of this project is to cause evolution at the University of Florida with respect to the financial, scientific, and other barriers to interdisciplinary research by employing management, administrative, and psychological teams. Successful achievement of this objective will enable additional activities similar to those described herein in order to advance the public health of the citizens of this nation not only for drug and chemical intoxication, but also for other seemingly intractable health problems.