DIAGNOSIS AND THERAPY OF DRUG AND CHEMICAL TOXICITY

药物和化学毒性的诊断和治疗

• 批准号: 7382208
• 负责人: BRIJ Mohan MOUDGIL
• 金额: $ 53.85万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7382208
• 关键词: DIAGNOSIS; THERAPY; DRUG; CHEMICAL; TOXICITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The diagnosis and therapy of drug and chemical toxicity is a significant public health problem and impacts millions of Americans with medical expenditures >$3 billion/year. This intractable public health threat remains for several reasons including a diverse number of toxic agents in multiple locations and patient classes, barriers to interdisciplinary research at the college and university level, and mechanisms of federal research support limited to single-investigator, hypothesis-driven, organ- or disease-specific studies. This proposal''s overall objective is to develop interdisciplinary research teams to address this intractable public health threat using art adapted engineered systems method of research advocated by the National Science Foundation. To our knowledge this paradigm of physical research has not heretofore been applied to these types of biomedical problems. This objective will be achieved by accomplishing the following specific aims: Specific Aim 1. Create a planning structure through which individuals from a variety of relevant disciplines can interact, research strategies can be developed, and institutional barriers to collaborative research can be addressed. Specific Aim 2. Identify and minimize institutional barriers to interdisciplinary collaboration. Specific Aim 3. Identify specific problems in the diagnosis and treatment of toxicity and develop research strategies to solve them. Specific Aim 4. Conduct pilot research to test the feasibility of selected research strategies identified in Aim 3 and to validate the planning approach. A secondary objective of this project is to cause evolution at the University of Florida with respect to the financial, scientific, and other barriers to interdisciplinary research by employing management, administrative, and psychological teams. Successful achievement of this objective will enable additional activities similar to those described herein in order to advance the public health of the citizens of this nation not only for drug and chemical intoxication, but also for other seemingly intractable health problems.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。描述（由申请人提供）： 药物和化学品毒性的诊断和治疗是一个重大的公共卫生问题，影响着数百万美国人，每年的医疗支出超过30亿美元。这一棘手的公共卫生威胁仍然存在的原因有几个，包括不同数量的有毒物质在多个地点和病人类，在学院和大学水平的跨学科研究的障碍，以及联邦研究支持的机制限于单一的研究者，假设驱动，器官或疾病的具体研究。该提案的总体目标是发展跨学科研究团队，使用美国国家科学基金会倡导的适应艺术的工程系统研究方法来解决这一棘手的公共卫生威胁。据我们所知，这种物理研究的范式迄今尚未应用于这些类型的生物医学问题。这一目标将通过实现以下具体目标来实现：具体目标1。创建一个规划结构，通过该结构，来自各种相关学科的个人可以进行互动，可以制定研究策略，并解决合作研究的制度障碍。 具体目标2。识别并尽量减少跨学科合作的制度障碍。 具体目标3。确定在诊断和治疗毒性的具体问题，并制定研究策略来解决这些问题。 具体目标4。进行先导研究，以测试目标3所确定的选定研究策略的可行性，并验证规划方法。 该项目的第二个目标是通过雇用管理，行政和心理团队，在佛罗里达大学促进跨学科研究的财务，科学和其他障碍的发展。这一目标的成功实现将使更多的活动类似于本文所述的，以促进这个国家的公民的公共健康，不仅对毒品和化学品中毒，而且对其他看似棘手的健康问题。