Role of Mu Opioid Receptor in Immune Function

Mu阿片受体在免疫功能中的作用

• 批准号: 7477471
• 负责人: Sabita Roy
• 金额: $ 12.67万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-10 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7477471
• 关键词: AIDS/HIV problem; Adrenalectomy; Area; Attenuated; Award; Behavioral; Biological; CD4 Positive T Lymphocytes; Cell Differentiation process; Cells; Cellular Immunity; Chronic; Clinical Research; Data; Defect; Dexamethasone; Disease Progression; Doctor of Philosophy; Drug abuse; Economics; Educational process of instructing; Effector Cell; Endorphins; Environment; Funding; Future; Goals; Grant; HIV; Helper-Inducer T-Lymphocyte; Hydrocortisone; Immune; Immune response; Immune system; Immunization; Immunosuppression; In Vitro; Independent Scientist Award; Infection; Injury; Interferon Type II; Investigation; Kansas; Life Experience; Mediating; Mediator of activation protein; Mentors; Minnesota; Modeling; Molecular; Morbidity - disease rate; Morphine; Mus; Naloxone; National Institute of Drug Abuse; Numbers; Opioid; Opioid Receptor; Opportunistic Infections; Pharmacology; Pneumococcal Pneumonia; Pneumococcal vaccine; Population; Predisposition; Process; Psychosocial Factor; Public Health; Regulation; Research; Research Personnel; Research Project Grants; Risk Factors; Role; Signal Transduction; Signal Transduction Pathway; Societies; Streptococcus pneumoniae; Stress; TNFRSF5 gene; Therapeutic immunosuppression; Thinking; Time; Training; Universities; Virus Diseases; Withdrawal; addiction; biological adaptation to stress; cost; cytokine; drug of abuse; human disease; hypothalamic-pituitary-adrenal axis; immune function; immunoregulation; in vivo; mortality; mouse model; mu opioid receptors; neurochemistry; opioid abuse; professor; receptor; restraint stress; skills; social

DESCRIPTION (provided by applicant): This is an application for a renewal of a NIDA sponsored K02 Independent Scientist Award. The candidate, Dr. Sabita Roy holds a Ph.D. degree from the University of Kansas, Lawrence and is a Professor in the Department of Pharmacology, University of Minnesota. She is currently funded by two independent grants; DA 12104 from NIDA/NIH-to study the effect of morphine on immune cells and DA 11806 from NIDA/NIH-to investigate the role mu opioid receptor on stress induced immunomodulation. This award will provide the candidate with release time to expand her research skills and enhance her ability for scientific investigations and mentoring. The long-term research goal of the candidate is to explore the molecular and cellular mechanism involved in morphine induced immunosupression and increased susceptibility to opportunistic infections such as S. pneumonia and HIV/AIDS. The candidate has already demonstrated using a murine model of S. pneumonia that morphine treatment significantly increases mortality and morbidity and accelerates disease progression. The major goal of the current application is to train in HIV/AIDS research as it relates to drug abuse and incorporate this line of research into her ongoing research projects. The training in HIV research will allow the candidate in future research to identify mechanisms by which drugs of abuse modulate HIV replication and or latency and if secondary opportunistic infection alter these processes. To achieve this goal release time will be utilized for mini sabbaticals and undertake training in HIV/AIDS research in the labs of eminent HIV/AIDS researchers. The KO 2 Award will facilitate this by relieving considerable amount of teaching and administrative duties. This plan has the full support of the Department of Pharmacology and the University of Minnesota.

描述（由申请人提供）：这是NIDA赞助的K 02独立科学家奖的续期申请。候选人萨比塔·罗伊博士拥有博士学位。他拥有堪萨斯大学劳伦斯分校的学位，是明尼苏达大学药理学系的教授。她目前由两个独立的赠款资助;来自NIDA/NIH的DA 12104研究吗啡对免疫细胞的影响，来自NIDA/NIH的DA 11806研究μ阿片受体在应激诱导的免疫调节中的作用。该奖项将为候选人提供释放时间，以扩大她的研究技能，提高她的科学调查和指导能力。候选人的长期研究目标是探索吗啡诱导的免疫抑制和增加对机会性感染（如沙门氏菌）易感性的分子和细胞机制。肺炎和艾滋病毒/艾滋病。该候选人已经使用S.吗啡治疗显著增加了死亡率和发病率，并加速了疾病的进展。目前申请的主要目标是在与药物滥用有关的艾滋病毒/艾滋病研究方面进行培训，并将这一研究方向纳入她正在进行的研究项目。艾滋病毒研究方面的培训将使未来研究的候选人能够确定滥用药物调节艾滋病毒复制和/或潜伏期的机制，以及继发性机会感染是否改变这些过程。为实现这一目标，将利用脱产时间进行短期休假，并在著名艾滋病毒/艾滋病研究人员的实验室进行艾滋病毒/艾滋病研究方面的培训。KO 2奖将通过减轻大量的教学和行政工作来促进这一点。该计划得到了明尼苏达大学药理学系的全力支持。