Microbial Genome Informatics Platform: a computational resource for comparative g

微生物基因组信息学平台：用于比较 g 的计算资源

• 批准号: 7613808
• 负责人: Lee Scott Katz
• 金额: $ 3.74万
• 依托单位: GEORGIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7613808
• 关键词: Microbial; Genome; Informatics; Platform; computational

DESCRIPTION (provided by applicant): We propose to create an online computational tool called the Microbial Genome Informatics Platform (MGIP), which will analyze multi-locus sequence typing (MLST) and have comparative genomics functionality. MGIP will be able to categorize strains of Neisseria meningitidis using MLST and will facilitate epidemiological studies worldwide. MGIP will be able to compare all complete genomes of Neisseria meningitidis and N. gonorrhoeae, including four as-of-yet unpublished N. meningitidis strains that we are assembling. Therefore, it is imperative to develop computational support to match the load of incoming data. Bacterial meningitis has about a 10% fatality rate plus another 15% with long-term sequelae. In sub-Saharan Africa, there can be up to 400,000 reported cases per year. MGIP falls in line with the CDC's goals of "People Prepared for Emerging Health Threats" because it will facilitate worldwide epidemiological studies of meningococcus and accelerate crucial genetic studies of hypervirulent strains.

描述（由申请人提供）： 我们建议创建一个名为微生物基因组信息平台（MGIP）的在线计算工具，该平台将分析多位点序列分型（MLST）并具有比较基因组学功能。MGIP将能够使用MLST对脑膜炎奈瑟菌菌株进行分类，并将促进全球流行病学研究。MGIP将能够比较脑膜炎奈瑟菌和脑膜炎奈瑟菌的所有完整基因组。淋病，包括四个尚未发表的N.脑膜 我们正在组装的菌株。因此，必须开发计算支持，以匹配传入数据的负载。细菌性脑膜炎的死亡率约为10%，另外15%有长期后遗症。在撒哈拉以南非洲，每年报告的病例可达40万例。MGIP福尔斯符合疾病预防控制中心的“人们为新出现的健康威胁做好准备”的目标，因为它将促进脑膜炎球菌的全球流行病学研究，并加速对高毒力菌株的关键遗传研究。