A Comparison of Electrical Impedance Myography and EMG in Radiculopathy

电阻抗肌电图与肌电图在神经根病中的比较

• 批准号: 7533029
• 负责人: Seward B. Rutkove
• 金额: $ 15.64万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7533029
• 关键词: Adopted; Automobile Driving; Blinded; Caring; Case Series; Categories; Cervical; Class; Clinical; Clinical Investigator; Collaborations; Communities; Complement; Condition; Data; Development; Devices; Diagnosis; Diagnostic Procedure; Disease; Electromyography; Electronics; Engineering; Environment; Evaluation; Expert Opinion; Frequencies; Funding; Goals; Gold; Grant; Hand; Hearing; Individual; Institutes; Invasive; Israel; Label; Lead; Localized; Massachusetts; Measurement; Medical center; Medicine; Mentors; Methods; Muscle; Myography; Needles; Neurology; Neuromuscular Diseases; Ownership; Pain; Painless; Paper; Patients; Persons; Process; Prospective Studies; Publishing; Radiculopathy; Rattus; Recruitment Activity; Research; Research Personnel; Retrospective Studies; Severities; Son; Standards of Weights and Measures; Stress; Structure; Surface; Techniques; Technology; Technology Transfer; Testing; Time; Today; Training; Universities; Work; base; career; clinical application; concept; design; diagnostic accuracy; electric impedance; expectation; experience; improved; medical schools; new technology; normal aging; novel diagnostics; patient oriented; patient oriented research; prospective; sex; success; technique development; theories

DESCRIPTION (provided by applicant): In this mid-career patient-oriented research application, the candidate, Dr. Seward Rutkove, proposes to pursue his long-term career goal of improving the assessment techniques used in the evaluation of patients with neuromuscular disorders and mentoring promising new investigators in neuromuscular disease research. Over the past 8 years, his major research effort has been in the development of the new technique of electrical impedance myography (EIM). EIM is a non-invasive, painless, approach to assessing muscle through the surface application and measurement of high-frequency, low-intensity electrical current. His research group has been pursuing the development of this technique through 3 separate short-term goals all of which have been grant supported: 1) the development of improved EIM electronics/engineering; 2) the development of an improved understanding of EIM theory; and 3) the clinical application, technology transfer, and dissemination of this technique. The environment supporting this work is rich and includes the Department of Neurology at Harvard Medical School/Beth Israel Deaconess Medical Center, where Dr. Rutkove is based. Dr. Rutkove has also established collaborations with engineers at Massachusetts Institute of Technology and physicists at Northeastern University, who have been assisting in device refinement and EIM theory development, respectively. In addition, this environment is especially conducive to the mentoring of new clinical investigators, with Dr. Rutkove already having substantial experience as a mentor. The research plan focuses on the blinded, prospective assessment of EIM versus EMG for use in the evaluation of two extremely common neuromuscular disorders: cervical and lumbosacral radiculopathy. The ultimate goal of this project is that of achieving Class I evidence supporting the value of the technique in the diagnosis of these neuromuscular conditions. The specific aims of the plan include: 1) A prospective, blinded evaluation of EIM and EMG in the diagnosis of cervical and lumbosacral radiculopathy; 2) a prospective, blinded evaluation of EIM and EMG in the evaluation of radiculopathy severity; 3. a prospective, blinded comparison of EIM and EMG in assessing the acuteness/chronicity of radiculopathy. A rich, structured, mentoring plan is also provided, including the expectation that young investigator's take ownership of individual projects during their training with Dr. Rutkove. Should this research prove EIM to be an effective test for the initial assessment of radiculopathy, the requirement for the painful, invasive test of needle EMG will be substantially reduced or possibly eliminated. This would lead to improved assessment and care for individuals suffering from this very common malady. Regardless of the specific success of EIM, a group of young investigators will be thoroughly trained to pursue patient-oriented neuromuscular disease research.

描述（由申请人提供）：在这项以患者为中心的职业生涯中期研究申请中，候选人 Seward Rutkov 博士提出追求其长期职业目标，即改进用于评估神经肌肉疾病患者的评估技术，并指导神经肌肉疾病研究中有前途的新研究人员。在过去的 8 年里，他的主要研究工作是开发电阻抗肌动描记术 (EIM) 新技术。 EIM 是一种无创、无痛的方法，通过表面应用和测量高频、低强度电流来评估肌肉。他的研究小组一直致力于通过 3 个独立的短期目标来开发这项技术，所有这些目标都得到了拨款支持：1）改进 EIM 电子/工程的开发； 2) 加深对 EIM 理论的理解； 3）该技术的临床应用、技术转让和传播。支持这项工作的环境非常丰富，包括 Rutkove 博士所在的哈佛医学院/贝斯以色列女执事医疗中心的神经病学系。 Rutkove 博士还与麻省理工学院的工程师和东北大学的物理学家建立了合作，他们分别协助设备改进和 EIM 理论开发。此外，这种环境特别有利于指导新的临床研究人员，Rutkove 博士已经拥有丰富的导师经验。该研究计划的重点是对 EIM 与 EMG 进行盲法、前瞻性评估，以评估两种极其常见的神经肌肉疾病：颈椎和腰骶神经根病。该项目的最终目标是获得 I 类证据，支持该技术在诊断这些神经肌肉疾病中的价值。该计划的具体目标包括：1）对EIM和EMG在颈椎和腰骶神经根病的诊断中进行前瞻性、盲法评估； 2) 在评估神经根病严重程度时对 EIM 和 EMG 进行前瞻性、盲法评估； 3. EIM 和 EMG 在评估神经根病的急性/慢性方面的前瞻性、盲法比较。还提供了丰富的、结构化的指导计划，包括期望年轻研究者在 Rutkove 博士的培训期间掌握各个项目的所有权。如果这项研究证明 EIM 是初步评估神经根病的有效测试，那么对针肌电图的痛苦、侵入性测试的需求将大大减少或可能消除。这将改善对患有这种非常常见疾病的个人的评估和护理。无论 EIM 取得具体成功，一群年轻的研究人员都将接受全面的培训，以开展以患者为导向的神经肌肉疾病研究。