A Comparison of Electrical Impedance Myography and EMG in Radiculopathy

电阻抗肌电图与肌电图在神经根病中的比较

• 批准号: 8076389
• 负责人: Seward B. Rutkove
• 金额: $ 15.64万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8076389
• 关键词: Age; Blinded; Caring; Cervical; Clinical Investigator; Collaborations; Development; Devices; Diagnosis; Disease; Disease remission; Electronics; Engineering; Environment; Evaluation; Frequencies; Goals; Grant; Individual; Institutes; Israel; Lead; Massachusetts; Measurement; Medical center; Mentors; Muscle; Myography; Needles; Neurology; Neuromuscular Diseases; Ownership; Pain; Painless; Patients; Radiculopathy; Research; Research Personnel; Severities; Severity of illness; Structure; Surface; Techniques; Technology; Technology Transfer; Testing; Training; Universities; Variant; Work; base; career; clinical application; cohort; electric impedance; expectation; experience; improved; medical schools; neuromuscular; neuromuscular disorder diagnosis; patient oriented; patient oriented research; prospective; success; technique development; theories

DESCRIPTION (provided by applicant): In this mid-career patient-oriented research application, the candidate, Dr. Seward Rutkove, proposes to pursue his long-term career goal of improving the assessment techniques used in the evaluation of patients with neuromuscular disorders and mentoring promising new investigators in neuromuscular disease research. Over the past 8 years, his major research effort has been in the development of the new technique of electrical impedance myography (EIM). EIM is a non-invasive, painless, approach to assessing muscle through the surface application and measurement of high-frequency, low-intensity electrical current. His research group has been pursuing the development of this technique through 3 separate short-term goals all of which have been grant supported: 1) the development of improved EIM electronics/engineering; 2) the development of an improved understanding of EIM theory; and 3) the clinical application, technology transfer, and dissemination of this technique. The environment supporting this work is rich and includes the Department of Neurology at Harvard Medical School/Beth Israel Deaconess Medical Center, where Dr. Rutkove is based. Dr. Rutkove has also established collaborations with engineers at Massachusetts Institute of Technology and physicists at Northeastern University, who have been assisting in device refinement and EIM theory development, respectively. In addition, this environment is especially conducive to the mentoring of new clinical investigators, with Dr. Rutkove already having substantial experience as a mentor. The research plan focuses on the blinded, prospective assessment of EIM versus EMG for use in the evaluation of two extremely common neuromuscular disorders: cervical and lumbosacral radiculopathy. The ultimate goal of this project is that of achieving Class I evidence supporting the value of the technique in the diagnosis of these neuromuscular conditions. The specific aims of the plan include: 1) A prospective, blinded evaluation of EIM and EMG in the diagnosis of cervical and lumbosacral radiculopathy; 2) a prospective, blinded evaluation of EIM and EMG in the evaluation of radiculopathy severity; 3. a prospective, blinded comparison of EIM and EMG in assessing the acuteness/chronicity of radiculopathy. A rich, structured, mentoring plan is also provided, including the expectation that young investigator's take ownership of individual projects during their training with Dr. Rutkove. Should this research prove EIM to be an effective test for the initial assessment of radiculopathy, the requirement for the painful, invasive test of needle EMG will be substantially reduced or possibly eliminated. This would lead to improved assessment and care for individuals suffering from this very common malady. Regardless of the specific success of EIM, a group of young investigators will be thoroughly trained to pursue patient-oriented neuromuscular disease research.

描述（由申请人提供）：在这项专业的以患者为导向的研究申请中，候选人Seward Rutkove博士提议追求他的长期职业生涯，以改善用于评估神经肌肉疾病的患者的评估技术，并指导神经肌肉疾病研究中有希望的新研究者。在过去的8年中，他的主要研究工作一直是开发新的电阻抗神秘技术（EIM）。 EIM是一种通过表面施用和高频，低强度电流的表面应用和测量来评估肌肉的无创，无痛的方法。他的研究小组一直通过3个单独的短期目标来追求这项技术的发展，所有这些都得到了支持：1）发展EIM电子/工程的改进； 2）发展对EIM理论的发展； 3）该技术的临床应用，技术转移和传播。支持这项工作的环境很丰富，包括哈佛医学院神经病学系/鲁特科夫（Rutkove）博士所在的贝丝以色列执事医疗中心。鲁特科夫（Rutkove）博士还与马萨诸塞州理工学院的工程师和东北大学的物理学家建立了合作，他们分别协助进行设备改进和EIM理论开发。此外，这种环境尤其有利于指导新的临床研究人员，而鲁特科夫博士已经拥有丰富的导师经验。该研究计划侧重于对EIM与EMG的盲目评估，用于评估两种极为常见的神经肌肉疾病：宫颈和腰椎radiculopathy。该项目的最终目标是实现I类证据，以支持该技术在这些神经肌肉疾病的诊断中的价值。该计划的具体目的包括：1）对EIM和EMG的前瞻性，盲目的评估，用于诊断宫颈和腰椎radiculopathy； 2）在评估放射性疾病严重程度时对EIM和EMG的前瞻性评估； 3。在评估辐射病的敏锐度/慢性时，EIM和EMG的前瞻性，盲目比较。还提供了一项丰富，结构化的指导计划，包括期望年轻的调查员在与鲁特科夫博士的培训期间掌握单个项目的所有权。如果这项研究证明EIM是对辐射病的初步评估的有效测试，那么对针头EMG的痛苦，侵入性测试的要求将大大减少或可能消除。这将导致对患有这种非常普遍的疾病的人的评估和护理。不管EIM的具体成功如何，一群年轻的研究人员将接受彻底培训，以进行以患者为导向的神经肌肉疾病研究。