Innovative Ultrasound Technology in Neuromuscular Disease

神经肌肉疾病的创新超声技术

• 批准号: 8875071
• 负责人: Seward B. Rutkove
• 金额: $ 15.26万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8875071
• 关键词: 21 year old; Address; Adoption; Adult; Age; Amyotrophic Lateral Sclerosis; Anisotropy; Area; Award; Biological Markers; Boston; Characteristics; Clinical; Clinical Investigator; Clinical Trials; Computer Assisted; Critical Illness; Data; Data Analyses; Databases; Development; Diagnostic; Diagnostic Procedure; Disease; Disease Progression; Disease remission; Disuse Atrophy; Duchenne muscular dystrophy; Elderly; Entropy; Environment; Evaluation; Faculty; Faculty Workshop; Funding; Future; Goals; Grant Review; Health; Individual; Israel; Limb structure; Measurement; Measures; Medical center; Mentors; Methods; Modality; Muscle; Muscular Dystrophies; Myopathy; Myositis; Neurologic; Neurology; Neuromuscular Diseases; Patient Care; Patients; Pediatric Hospitals; Publishing; Radiculopathy; Recruitment Activity; Reproducibility; Research; Research Activity; Research Personnel; Research Support; Resources; Series; Severity of illness; Signal Transduction; Staging; System; Techniques; Technology; Therapeutic Clinical Trial; Time; Tissues; Ultrasonography; Work; Writing; base; career; disease diagnosis; elastography; imaging Segmentation; imaging modality; improved; indexing; innovation; interest; medical schools; meetings; member; neuromuscular; novel; novel diagnostics; patient oriented; patient oriented research; pressure; quantitative ultrasound; radiofrequency; rapid technique; response; tool

DESCRIPTION (provided by applicant): In this renewal of his mid-career investigator award in patient oriented-research, the candidate, Dr. Seward Rutkove, proposes to develop his mentoring efforts with young investigators in neurological research while continuing the pursuit of his long-term career goal of improving neuromuscular diagnostic techniques. Dr. Rutkove plans to mentor two specific groups of individuals, as he has been doing devotedly since his first K24 was funded in 2008. The first group of individuals consists of junior neurology faculty members, most of who work outside of Dr. Rutkove's subspecialty of neuromuscular disease. For these individuals, he will continue to hold regular, one-on-one meetings and will continue to organize a faculty seminar series to help share and generate research ideas. In addition, he will expand a 3X/year grant review and discussion meeting in which investigators, both junior and more senior, can examine individual researcher's specific aims and research ideas in an open forum. The second group of mentees generally consists of residents and fellows whose long- term goal is to become a successful patient-oriented researcher in neuromuscular disease, but who have not yet identified a specific area of research. For these individuals, Dr. Rutkove will take a more "hands-on" approach with regular one-on-one meetings and detailed guidance in identifying potential areas of research. It is also this group of individuals who will benefit most directly from Dr. Rutkove's proposed K-24-supported research in quantitative diagnostic ultrasound techniques for the evaluation of neuromuscular disease, since this area offers broad opportunities for new research directions and opportunities. Specifically, Dr. Rutkove's proposed research plan focuses on the development of a variety of innovative ultrasound-based tools for the assessment of muscle, including automated signal decomposition of the backscattered radiofrequency data, computer-assisted image segmentation, and volumetric, electrographic, anisotropic, and entropy-based analyses. These techniques will be applied to a broad group of adult subjects with neuromuscular disease, providing ample opportunity for mentees to both participate directly in patient-oriented research and to identify areas of research interest of ther own. The environment supporting this work is rich and includes the resources at the Department of Neurology at Harvard Medical School/Beth Israel Deaconess Medical Center, where Dr. Rutkove is based. In addition to these mentoring and research activities, during the funding period, Dr. Rutkove also plans on writing and publishing a guide for researchers interested in establishing a career in patient-oriented research, through Springer publishing. At the conclusion of the research period, Dr. Rutkove expects to have advanced the area of clinical neuromuscular disease research while helping launch the successful careers of a new set of clinical investigators.

描述（由申请人提供）：在他在他的中期研究者授予患者研究人员奖的这一裁员中，候选人Seward Rutkove博士建议在神经学研究中与年轻的研究人员一起发展他的指导工作，同时继续追求他的长期职业生涯目标，以改善神经性肌肉诊断。鲁特科夫（Rutkove）博士计划指导两个特定的人群，因为自从他的第一个K24于2008年获得资助以来，他一直在忠实地做。第一组由初级神经病学教师组成，大多数人在鲁特科夫（Rutkove）博士的神经肌肉疾病的副业以外工作。对于这些人来说，他将继续举行定期的一对一会议，并将继续组织一个教师研讨会系列，以帮助分享和产生研究思想。此外，他将扩大3倍/年的赠款和讨论会议，在开放论坛上，调查人员（大三和更多的人）都可以研究个人研究人员的具体目的和研究思想。第二组受训者通常由居民和研究员组成，他们的长期目标是成为一个成功的以患者为导向的神经肌肉疾病的研究人员，但尚未确定特定的研究领域。对于这些人来说，鲁特科夫博士将采取更“动手”的方法，并定期一对一的会议和详细指导，以识别潜在的研究领域。也是这群人将受益最大 直接来自鲁特科夫（Rutkove）博士提议的K-24支持的研究，用于评估神经肌肉疾病的定量诊断超声技术，因为该领域为新的研究方向和机会提供了广泛的机会。具体而言，鲁特科夫（Rutkove）博士提出的研究计划着重于开发用于评估肌肉的各种创新超声的工具，包括反向散射的辐射射频数据的自动信号分解，计算机辅助图像细分，以及大量的，大量的，电脑，电视，畸形，基于熵的分析。这些技术将应用于一群具有神经肌肉疾病的成年受试者，为受训者提供了充足的机会，可以直接参与以患者为导向的研究，并确定其自己的研究兴趣领域。支持这项工作的环境很丰富，包括哈佛医学院神经病学系的资源/贝丝·以色列执事医疗中心，鲁特科夫（Rutkove）博士所在。除了这些指导和研究活动外，在资助期间，鲁特科夫博士还计划撰写和发布有兴趣通过Springer Publishing建立以患者为导向的研究职业的研究人员指南。在研究期结束时，鲁特科夫（Rutkove）博士预计将在临床神经肌肉疾病研究的领域推进，同时帮助启动了一组新的临床研究者的成功职业。