Career Development in the Mechanisms of Deep Brain Stimulation

这个项目将使Dorval博士成为运动障碍和脑深部刺激的未来研究者 （DBS）。该奖项将为Dorval博士提供受保护的时间，以参加神经工程课程， 在临床旋转，并学习所需的实验技术，建立自己作为一个独立的 研究员作为这项提议的一部分，多瓦尔博士组建了一个职业发展委员会， 研究人员和临床医生来指导他的进展。该奖项将资助多瓦尔博士进行动物，临床 和计算研究，将量化DBS的信号处理效果，并为他提供时间 发表他的研究结果，并准备未来的赠款，以建立自己的实验室。 Dorval博士将量化受运动障碍影响的大脑区域的信息处理， 帕金森氏病（PD）或特发性震颤（ET）。DBS缓解了某些个体的症状，但也可能是 对其他人无效或引起使人衰弱的副作用。DBS如何修改信号处理的知识， 大脑的运动区域将加速DBS模式的设计，更好地缓解症状。这项工作 将利用信息论的工具来分析受影响地区之间的关系， 在疾病发作后，以及存在临床使用的和最近假设的DBS模式的情况下。 在这个项目中，Dorval博士将在PD模型的运动区域中记录多电极阵列（MEA） 收集PD和ET患者的临床数据，并制作计算机模型，联合收割机和解释 生物学结果。Nicolelis博士以其在大鼠中的MEA工作而闻名于世。特纳医生是一位 DBS手术和技术的领导者。最重要的是，基金导师格里尔博士是计算机领域的先驱 DBS效应模型和一位经验丰富的实验者，具有成功的临床合作历史。 在杜克大学工作，与这些顾问和其他资助者一起，多瓦尔博士是独一无二的。 定位既发展他的技能，作为一个DBS研究人员，并取得重大进展，了解 DBS缓解运动障碍症状的机制。 该项目将揭示大脑信息处理如何被运动障碍所改变， 帕金森氏病和脑深部电刺激（DBS）的治疗。如果成功，该项目将 改善现有患者的治疗，增加DBS有效的个体数量。

This project will develop Dr. Dorval as a future researcher in motor-disorders and deep brain stimulation (DBS). This award will provide Dr. Dorval with protected time to take neural engineering courses, participate in clinical rotations, and learn the experimental techniques required to establish himself as an independent researcher. As part of this proposal, Dr. Dorval has assembled a career development committee made of researchers and clinicians to guide his progress. The award will fund Dr. Dorval to perform animal, clinical and computational research that will quantify the signal processing effects of DBS,and provide time for him to publish his results and prepare future grants with which to establish his own laboratory. Dr. Dorval will quantify the information processing in brain regions affected by motor-disorders such as Parkinson's disease (PD)or essential tremor (ET).DBS alleviates symptoms in some individuals, but can be ineffective or induce debilitating side effects in others. Knowledge of how DBS modifies signal processing in motor regions of the brain will hasten the design of DBS patterns better able to relieve symptoms. This work will utilize the tools of information theory to analyze the relationships between affected regions before and after disease onset, and in presence of clinically-used and recently-hypothesized patterns ofDBS. In this project, Dr. Dorval will record from multi-electrode arrays (MEAs) in motor-regions of a PD-model in the rat;gather clinical data from PD and ET patients; and craft computer models that combine and explain the biological results. Dr. Nicolelis is world reknown for his MEA work in rats. Dr. Turner is an established leader in DBS surgery and techniques. Most significantly, the grant mentor Dr. Grill is a pioneer in computer models of DBS effects and an experienced experimentalist with a history of successful clinical collaborations. Working at Duke University, with these advisers and the other grant contributors, Dr. Dorval is uniquely positioned to both develop his skills as a DBS researcher and make significant progress in understanding the mechanisms of motor-disorder symptom alleviation byDBS. This project will reveal how brain information processing is modified by motor-disorders such as Parkinson's Disease and by the treatment of deep brain stimulation (DBS). If successful, this project will improve treatment for existing patients and increase the number of individuals for whom DBS is effective.