Career Development in the Mechanisms of Deep Brain Stimulation

这个项目将使多瓦尔博士成为未来运动障碍和脑深部刺激领域的研究人员。 (星展)。这一奖项将为多瓦尔博士提供受保护的时间来参加神经工程课程，参与 在临床轮换中，并学习建立自己作为独立医生所需的实验技术 研究员。作为这项提议的一部分，多瓦尔博士组建了一个职业发展委员会，由 研究人员和临床医生指导他的进步。该奖项将资助多瓦尔博士进行动物、临床 以及计算研究，将量化星展银行的信号处理效果，并为他提供时间 发表他的研究成果，并准备未来用于建立自己的实验室的拨款。 多瓦尔博士将量化受运动障碍影响的大脑区域的信息处理，例如 帕金森氏病(PD)或原发性震颤(ET)。DBS可以缓解某些人的症状，但也可以 对其他人无效或引起衰弱的副作用。了解DBS如何修改中的信号处理 大脑的运动区将加速设计能够更好地缓解症状的DBS模式。这部作品 将利用信息论的工具来分析之前受影响地区和 在疾病发作后，并存在临床使用的和最近假想的DBS模式。 在这个项目中，多瓦尔博士将从PD模型运动区的多电极阵列(MEA)进行记录 收集PD和ET患者的临床数据；制作计算机模型，结合和解释 生物学上的结果。尼科利斯博士因其在老鼠体内的MEA研究而闻名于世。特纳博士是一位老牌的 星展银行手术和技术领域的领先者。最重要的是，资助导师Grill博士是计算机领域的先驱 DBS效应模型和一位有成功临床合作历史的经验丰富的实验者。 在杜克大学工作，与这些顾问和其他赠款捐赠者一起，多瓦尔博士是独一无二的 既能发展自己作为星展银行研究员的技能，又能在理解 丹参改善运动障碍症状的机制。 这个项目将揭示大脑信息处理是如何被运动障碍改变的，比如 帕金森氏症和脑深部刺激(DBS)治疗。如果成功，这个项目将 改善对现有患者的治疗，增加DBS有效的个人数量。

This project will develop Dr. Dorval as a future researcher in motor-disorders and deep brain stimulation (DBS). This award will provide Dr. Dorval with protected time to take neural engineering courses, participate in clinical rotations, and learn the experimental techniques required to establish himself as an independent researcher. As part of this proposal, Dr. Dorval has assembled a career development committee made of researchers and clinicians to guide his progress. The award will fund Dr. Dorval to perform animal, clinical and computational research that will quantify the signal processing effects of DBS,and provide time for him to publish his results and prepare future grants with which to establish his own laboratory. Dr. Dorval will quantify the information processing in brain regions affected by motor-disorders such as Parkinson's disease (PD)or essential tremor (ET).DBS alleviates symptoms in some individuals, but can be ineffective or induce debilitating side effects in others. Knowledge of how DBS modifies signal processing in motor regions of the brain will hasten the design of DBS patterns better able to relieve symptoms. This work will utilize the tools of information theory to analyze the relationships between affected regions before and after disease onset, and in presence of clinically-used and recently-hypothesized patterns ofDBS. In this project, Dr. Dorval will record from multi-electrode arrays (MEAs) in motor-regions of a PD-model in the rat;gather clinical data from PD and ET patients; and craft computer models that combine and explain the biological results. Dr. Nicolelis is world reknown for his MEA work in rats. Dr. Turner is an established leader in DBS surgery and techniques. Most significantly, the grant mentor Dr. Grill is a pioneer in computer models of DBS effects and an experienced experimentalist with a history of successful clinical collaborations. Working at Duke University, with these advisers and the other grant contributors, Dr. Dorval is uniquely positioned to both develop his skills as a DBS researcher and make significant progress in understanding the mechanisms of motor-disorder symptom alleviation byDBS. This project will reveal how brain information processing is modified by motor-disorders such as Parkinson's Disease and by the treatment of deep brain stimulation (DBS). If successful, this project will improve treatment for existing patients and increase the number of individuals for whom DBS is effective.