Career Development in the Mechanisms of Deep Brain Stimulation

深部脑刺激机制的职业发展

• 批准号: 7546986
• 负责人: ALAN D DORVAL
• 金额: $ 11.22万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7546986
• 关键词: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adverse effects; Affect; Animals; Area; Award; Basal Ganglia; Behavior; Biological; Biological Neural Networks; Bradykinesia; Brain; Brain region; Clinical; Clinical Data; Collaborations; Computer Simulation; Corpus striatum structure; Data; Deep Brain Stimulation; Development; Disease; Disease model; Electrodes; Engineering; Entropy; Essential Tremor; Excision; Exposure to; Foundations; Frequencies; Funding; Future; Generic Drugs; Grant; Implant; Individual; Information Theory; Knowledge; Laboratories; Learning; Lesion; Light; Link; Macaca mulatta; Maps; Measures; Mentors; Misinformation; Modeling; Monitor; Motor; Motor output; Muscle; Neurons; Noise; Onset of illness; Operative Surgical Procedures; Output; Oxidopamine; Parkinson Disease; Patients; Pattern; Physiologic pulse; Positioning Attribute; Primates; Publishing; Rattus; Recording of previous events; Research; Research Personnel; Rodent; Rotation; Severities; Signal Transduction; Structure of subthalamic nucleus; Symptoms; Techniques; Testing; Thalamic structure; Time; Tremor; Universities; Visual; Work; base; career development; clinical efficacy; computerized data processing; design; effective therapy; experience; improved; information processing; motor disorder; nervous system disorder; novel; pressure; programs; relating to nervous system; response; skills; sound; tool

This project will develop Dr. Dorval as a future researcher in motor-disorders and deep brain stimulation (DBS). This award will provide Dr. Dorval with protected time to take neural engineering courses, participate in clinical rotations, and learn the experimental techniques required to establish himself as an independent researcher. As part of this proposal, Dr. Dorval has assembled a career development committee made of researchers and clinicians to guide his progress. The award will fund Dr. Dorval to perform animal, clinical and computational research that will quantify the signal processing effects of DBS,and provide time for him to publish his results and prepare future grants with which to establish his own laboratory. Dr. Dorval will quantify the information processing in brain regions affected by motor-disorders such as Parkinson's disease (PD)or essential tremor (ET).DBS alleviates symptoms in some individuals, but can be ineffective or induce debilitating side effects in others. Knowledge of how DBS modifies signal processing in motor regions of the brain will hasten the design of DBS patterns better able to relieve symptoms. This work will utilize the tools of information theory to analyze the relationships between affected regions before and after disease onset, and in presence of clinically-used and recently-hypothesized patterns ofDBS. In this project, Dr. Dorval will record from multi-electrode arrays (MEAs) in motor-regions of a PD-model in the rat;gather clinical data from PD and ET patients; and craft computer models that combine and explain the biological results. Dr. Nicolelis is world reknown for his MEA work in rats. Dr. Turner is an established leader in DBS surgery and techniques. Most significantly, the grant mentor Dr. Grill is a pioneer in computer models of DBS effects and an experienced experimentalist with a history of successful clinical collaborations. Working at Duke University, with these advisers and the other grant contributors, Dr. Dorval is uniquely positioned to both develop his skills as a DBS researcher and make significant progress in understanding the mechanisms of motor-disorder symptom alleviation byDBS. This project will reveal how brain information processing is modified by motor-disorders such as Parkinson's Disease and by the treatment of deep brain stimulation (DBS). If successful, this project will improve treatment for existing patients and increase the number of individuals for whom DBS is effective.

该项目将发展Dorval博士，成为未来的运动抑制作用和深脑刺激的研究人员 （DBS）。该奖项将为Dorval博士提供受保护的时间参加神经工程课程，参加 在临床轮换中，学习确立自己为独立所需的实验技术 研究员。作为该提案的一部分，多瓦尔博士召集了一个职业发展委员会 研究人员和临床医生指导他的进步。该奖项将资助Dorval博士进行动物，临床 以及将量化DBS信号处理效果的计算研究，并为他提供时间 发表他的结果并准备未来的赠款，以建立自己的实验室。 Dorval博士将量化受电机疾病影响的大脑区域的信息处理，例如 帕金森氏病（PD）或基本震颤（ET）.DBS减轻某些人的症状，但可以是 其他人无效或引起使人衰弱的副作用。了解DB如何修改信号处理的知识 大脑的运动区域将加快DBS模式的设计，以更好地缓解症状。这项工作 是否会利用信息理论的工具来分析受影响区域之前和之前的关系 疾病发作后，以及在临床中使用近期和近期促成的模式的情况下。 在这个项目中，Dorval博士将在PD模型的电动区中从多电极阵列（MEA）记录 在大鼠中；从PD和ET患者那里收集临床数据；和组合和解释的计算机模型 生物学结果。 Nicolelis博士因其在老鼠中的MEA工作而闻名。特纳博士是一个既定的 DBS手术和技术的领导者。最重要的是，赠款导师烧烤博士是计算机的先驱 DBS效应的模型和经验丰富的实验学家，具有成功的临床合作历史。 Dorval博士在杜克大学（Duke University 既可以发展他作为DBS研究人员的技能，又要在理解方面取得重大进展 运动症状症状的机制减轻BYDB。 该项目将揭示大脑信息处理如何通过电动机（例如 帕金森氏病并通过治疗深脑刺激（DBS）。如果成功，这个项目将 改善现有患者的治疗，并增加DBS有效的个体数量。