Career Development:Mechanisms of Deep Brain Stimulation

职业发展：脑深部刺激机制

• 批准号: 7017889
• 负责人: ALAN D DORVAL
• 金额: $ 10.58万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7017889
• 关键词: Parkinson' s disease; animal data; basal ganglia; biological models; brain electronic stimulator; clinical research; computer data analysis; degenerative motor system disease; disease /disorder model; human subject; laboratory rat; methylphenyltetrahydropyridine; neural information processing; patient oriented research; psychomotor function; thalamus; training; tremor

DESCRIPTION (provided by applicant): This project will develop Dr. Dorval as a future researcher in motor-disorders and deep brain stimulation (DBS). This Award will provide Dr. Dorval with protected time to take neural engineering courses, participate in clinical rotations and learn the experimental techniques required to establish himself as an independent researcher. As part of this proposal, Dr. Dorval has assembled a career development committee made of researchers and clinicians to guide his progress. The Award will fund Dr. Dorval to perform animal, clinical and computational research that will quantify the signal processing effects of DBS, and provide time for him to publish his results and prepare future grants with which to establish his own laboratory. Dr. Dorval will quantify the information processing in brain regions affected by motor-disorders such as Parkinson's disease (PD) or essential tremor (ET). DBS alleviates symptoms in some individuals, but can be ineffective or induce debilitating side effects in others. Knowledge of how DBS modifies signal processing in motor regions of the brain will hasten the design of DBS patterns better able to relieve symptoms. This work will utilize the tools of information theory to analyze the relationships between affected regions before and after disease onset, and in presence of clinically-used and recently-hypothesized patterns of DBS. In this project, Dr. Dorval will record from multi-electrode arrays (MEAs) in motor-regions of a PD-model in the rat; gather clinical data from PD and ET patients; and craft computer models that combine and explain the biological results. Dr. Nicolelis is world-known for his MEA work in rats. Dr. Turner is an established leader in DBS surgery and techniques. Most significantly, the grant mentor Dr. Grill is a pioneer in computer models of DBS effects and an experienced experimentalist with a history of successful clinical collaborations. Working at Duke University, with these advisers and the other grant contributors, Dr. Dorval is uniquely positioned to both develop his skills as a DBS researcher and make significant progress in understanding the mechanisms of motor-disorder symptom alleviation by DBS. This project will reveal how brain information processing is modified by motor-disorders such as Parkinson's disease and by the treatment of deep brain stimulation (DBS). If successful, this project will improve treatment for existing patients and increase the number of individuals for whom DBS is effective.

描述（由申请人提供）：该项目将发展Dorval博士，成为未来的运动抑制作用和深脑刺激（DBS）的研究人员。该奖项将为Dorval博士提供受保护的时间，以参加神经工程课程，参加临床轮换并学习确立自己为独立研究人员所需的实验技术。作为该提案的一部分，Dorval博士组建了一个由研究人员和临床医生组成的职业发展委员会，以指导他的进步。该奖项将资助Dorval博士，进行动物，临床和计算研究，以量化DBS的信号处理效果，并为他提供时间发布其结果并为建立自己的实验室的未来赠款提供时间。 Dorval博士将量化受帕金森氏病（PD）或Essential Tremor（ET）等运动区域影响的大脑区域的信息处理。 DB会减轻某些人的症状，但可能无效或引起其他人的副作用。了解DBS如何修饰大脑运动区域的信号处理将加速DBS模式的设计，以更好地缓解症状。这项工作将利用信息理论的工具来分析疾病发作前后受影响区域之间的关系，以及在临床中使用和最近促成的DBS模式的情况下。在这个项目中，Dorval博士将从大鼠的PD模型的电动区中从多电极阵列（MEA）记录。从PD和ET患者那里收集临床数据；以及结合和解释生物学结果的计算机模型。 Nicolelis博士以他在老鼠的MEA工作而闻名。特纳博士是DBS手术和技术领域的知名领导者。最重要的是，Grant导师Grill博士是DBS效果计算机模型的先驱，并且是经验丰富的实验者，具有成功的临床合作历史。 Dorval博士在杜克大学（Duke University）与这些顾问和其他赠款贡献者一起工作，既可以发展他作为DBS研究人员的技能，又在理解DBS减轻运动问题的机制方面取得了重大进展。该项目将揭示大脑信息处理如何通过帕金森氏病（Parkinson's Diseation）等运动抑制作用以及深度脑刺激（DBS）的治疗来改变。如果成功，该项目将改善现有患者的治疗，并增加DBS有效的个体数量。