SIGNET

西格内特

• 批准号: BB/F003838/1
• 负责人: Markus Owen
• 金额: $ 10.39万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FF003838%2F1
• 关键词: SIGNET

Cell signalling is at the frontier of investigation of cells, tissues and organisms, both in the animal and plant kingdoms. The study of cell signalling is becoming the cornerstone in understanding how cells and cell populations perceive and interact with the external world. Importantly, in all natural systems, cell signaling pathways interact with one another to form networks, both within and between cells, that can behave in complex and unexpected ways. Our understanding of cell signalling is hindered by this inherent complexity, and future analyses of cell signaling networks will require a synergistic combination of experimental and theoretical approaches including the development and analysis of simulations and models. A Cell Signalling Network will bring together a number of internationally renowned researchers from biology and the mathematical sciences. This group activity will enhance the development of innovative techniques that could not be achieved in isolation. A truly interdisciplinary network devoted to the study of cell signalling will engage life scientists and mathematicians in developing new approaches and methodologies to improve our understanding of cell signalling in a variety of contexts, including normal development, wound healing, and disease.

细胞信号传导处于动物界和植物界细胞、组织和生物体研究的前沿。细胞信号传导的研究正在成为理解细胞和细胞群如何感知外部世界并与之相互作用的基石。重要的是，在所有自然系统中，细胞信号传导途径彼此相互作用，形成细胞内部和细胞之间的网络，这些网络可以以复杂且意想不到的方式发挥作用。这种固有的复杂性阻碍了我们对细胞信号传导的理解，未来对细胞信号传导网络的分析将需要实验和理论方法的协同组合，包括模拟和模型的开发和分析。细胞信号网络将汇集许多来自生物学和数学科学的国际知名研究人员。该小组活动将促进单独无法实现的创新技术的开发。一个致力于细胞信号传导研究的真正的跨学科网络将让生命科学家和数学家参与开发新的方法和方法，以提高我们对各种情况下的细胞信号传导的理解，包括正常发育、伤口愈合和疾病。