NETWORK: ANGIONET - Interdisciplinary Angiogenesis Network

网络：ANGIONET - 跨学科血管生成网络

• 批准号: EP/D501083/1
• 负责人: Markus Owen
• 金额: $ 8.07万
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD501083%2F1
• 关键词: NETWORK; ANGIONET; Interdisciplinary; Angiogenesis; Network

Angiogenesis is the process by which new blood vessels are formed, and it plays a major role in normal development and a number of medical conditions such as cancer, vascular disease, rheumatoid arthritis, and impaired wound healing. However, our understanding of angiogenesis is critically retarded by its inherent complexity and consequent recalcitrance to the application of standard biological methodologies. An Angiogenesis Network will bring together a number of internationally renowned researchers from multiple disciplines within biology, medicine, engineering, and the physical sciences. This group activity will enhance the development of innovative techniques that could not be achieved in isolation. A truly interdisciplinary network devoted to the study of angiogenesis will engage life scientists, clinicians, engineers and physical scientists in developing new approaches and methodologies to improve our understanding of angiogenesis in a variety of contexts, including normal development, wound healing, tumour growth, and tissue engineering.The Network will establish and maintain a multi-disciplinary research consortium interested in determining the mechanisms controlling new blood vessel formation. A series of workshops will allow for the presentation of frontier research, encourage extensive discussion, generate important new projects and techniques, and promote a sense of community. In addition, the Network will embody an openness to new ideas and concepts, and to input from less established participants. This will enable them to develop personal contacts with more senior researchers, and contribute to the development of a new generation of scientists that transcend the traditional barriers between disciplines. An important target is to involve the full range of engineering and the physical sciences, including experimental and computational chemistry, engineering, mathematics, physics, information science and materials science. This very broad range of expertise is a particularly exciting feature of the Network, and should lead to a number of novel, unexpected, and adventurous collaborations.

血管生成是形成新血管的过程，它在正常发育和许多疾病中发挥着重要作用，如癌症、血管疾病、类风湿性关节炎和创面愈合不良。然而，我们对血管生成的理解因其固有的复杂性和随之而来的对标准生物学方法应用的抵触而严重受阻。血管生成网络将汇集来自生物学、医学、工程学和物理科学领域的多个学科的许多国际知名研究人员。这一小组活动将促进创新技术的发展，这些技术是无法孤立实现的。一个致力于血管生成研究的真正的跨学科网络将吸引生命科学家、临床医生、工程师和物理学家开发新的途径和方法，以提高我们对各种背景下的血管生成的理解，包括正常发育、伤口愈合、肿瘤生长和组织工程。该网络将建立和维持一个多学科研究联盟，对确定控制新血管形成的机制感兴趣。一系列研讨会将允许介绍前沿研究，鼓励广泛讨论，产生重要的新项目和技术，并促进社区意识。此外，该网络将体现对新的想法和概念的开放，以及对不太成熟的参与者的投入。这将使他们能够与更资深的研究人员发展个人联系，并为培养超越学科之间传统障碍的新一代科学家做出贡献。一个重要的目标是全面涉及工程和物理科学，包括实验和计算化学、工程学、数学、物理学、信息科学和材料科学。这种非常广泛的专业知识是该网络的一个特别令人兴奋的特点，应该会导致一些新颖、意想不到和冒险的合作。

项目成果

Mathematical modeling predicts synergistic antitumor effects of combining a macrophage-based, hypoxia-targeted gene therapy with chemotherapy.

• DOI: 10.1158/0008-5472.can-10-2834
• 发表时间: 2011-04-15
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Owen MR;Stamper IJ;Muthana M;Richardson GW;Dobson J;Lewis CE;Byrne HM
• 通讯作者: Byrne HM

Multiscale modelling of vascular tumour growth in 3D: the roles of domain size and boundary conditions.

• DOI: 10.1371/journal.pone.0014790
• 发表时间: 2011-04-13
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Perfahl H;Byrne HM;Chen T;Estrella V;Alarcón T;Lapin A;Gatenby RA;Gillies RJ;Lloyd MC;Maini PK;Reuss M;Owen MR
• 通讯作者: Owen MR

Modelling the role of angiogenesis and vasculogenesis in solid tumour growth.

模拟血管生成和血管生成在实体瘤生长中的作用。

• DOI: 10.1007/s11538-007-9253-6
• 发表时间: 2007
• 期刊: Bulletin of mathematical biology
• 影响因子: 3.5
• 作者: Stamper,IJ;Byrne,HM;Owen,MR;Maini,PK
• 通讯作者: Maini,PK