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Integrative modelling of morphogenetic epithelial patterning and polarity

形态发生上皮图案和极性的综合建模

基本信息

批准号：
EP/C539044/1
负责人：
Markus Owen
金额：
$ 17.07万
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2006
资助国家：
英国
起止时间：
2006 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FC539044%2F1
关键词：
Integrative modelling morphogenetic epithelial patterning

项目摘要

The science of animal development from a fertilised egg to an adult is not just important from a fundamental scientific point of view, but also because it has much to offer for our understanding of diseases such as cancer. Even the growth and development of the humble fruit fly has much to tell us about human biology. Mathematical modelling is increasingly seen as a valuable tool to help us understand the complex issues that arise in biology. This project will use a range of mathematical models and techniques to study the communication between cells that is essential for animal development.A linked set of mathematical models will describe the amazing way that cells can organise themselves into precise patterns like those found in the compound eye of insects. This involves the movement of a wave of activity across the developing eye, the formation of patterns behind that wave, and the synchronised rotation of clusters of cells called ommatidia. A fusion of the latest ideas on the generation of such patterns will provide a clear modelling framework that can distinguish between various mechanisms. Dr David Strutt (Department of Developmental Genetics, University of Sheffield) will support this work with his considerable expertise in the biology of tissue patterning. The project will develop simple models that give insight and are mathematically manageable, and more complex computer models based on details of the underlying biology. The work will require the analysis of waves and pattern formation, using a variety of powerful mathematical techniques. The project will also help to train the next generation of scientists to work across the traditional boundaries between disciplines.

动物从受精卵到成年的发育科学不仅从基础科学的角度来看很重要，而且还因为它对我们理解癌症等疾病有很大帮助。即使是不起眼的果蝇的生长和发育也能告诉我们很多关于人类生物学的信息。数学建模越来越被视为一种有价值的工具，可以帮助我们理解生物学中出现的复杂问题。该项目将使用一系列数学模型和技术来研究细胞之间的通信，这对动物发育至关重要。一组相互关联的数学模型将描述细胞可以将自己组织成精确模式的惊人方式，就像昆虫复眼中发现的那样。这涉及到一波活动穿过发育中的眼睛的运动，波后图案的形成，以及称为小眼的细胞群的同步旋转。关于生成这种模式的最新想法的融合将提供一个明确的建模框架，可以区分各种机制。大卫斯特拉特博士（发育遗传学系，谢菲尔德大学）将支持他在组织图案生物学相当专业的这项工作。该项目将开发简单的模型，提供洞察力和数学管理，以及基于基础生物学细节的更复杂的计算机模型。这项工作将需要使用各种强大的数学技术来分析波浪和图案的形成。该项目还将有助于培养下一代科学家，使他们能够跨越学科之间的传统界限。