Sleep Apnea: Determinants and Consequences

睡眠呼吸暂停：决定因素和后果

• 批准号: 7413726
• 负责人: M. Safwan Badr
• 金额: $ 9.19万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7413726
• 关键词: Airway Resistance; Award; Beds; Biological Assay; Biomedical Engineering; Breathing; Caliber; Carbon Dioxide; Chest; Clinical; Clinical Research; Collaborations; Complex; Computers; Continuous Positive Airway Pressure; Data; Data Storage and Retrieval; Development; Diamond; Discipline of obstetrics; Doctor of Medicine; Doctor of Philosophy; Educational Curriculum; Enrollment; Equipment; Faculty; Fellowship; Future; Gonadal Steroid Hormones; Growth; Gynecology; Hospitals; Human; Hypoxia; Image; Laboratories; Laboratory Research; Legal patent; Lung; Mechanical Ventilators; Medical Research; Medical center; Medicine; Mentors; Methodology; Methods; Michigan; Muscle; Nose; Physicians; Physiology; Poaceae; Postdoctoral Fellow; Principal Investigator; Process; Publications; Pump; REM Sleep; Recruitment Activity; Relative (related person); Reproductive Endocrinology; Research; Research Personnel; Research Project Grants; Resources; Secure; Site; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Snoring; Staging; Students; Thinking; Time; Universities; Veterans; Work; Workplace; Writing; base; career; data acquisition; digital; interest; lymphocyte transforming factor; male; member; pharyngeal critical pressure; pre-doctoral; pressure; professor; programs; skills

DESCRIPTION (provided by applicant): The key objective of this proposal is to provide protected time for the applicant to serve as a mentor for students, trainees, and junior faculty. The mentoring vehicle will consist of two research projects focusing on the effects of male sex hormones on breathing during sleep and the determinants of long term-facilitation during sleep. The research plan is focused on the effects of male sex hormones on breathing during sleep. The specific aims are: 1. To investigate the occurrence and determinants of LTF in sleeping humans. We hypothesize that LTF can be activated by repetitive hypoxia in sleeping humans especially subjects with snoring and inspiratory flow limitation. 2. To determine whether LTF results in increased pharyngeal caliber and amelioration of inspiratory flow limitation. We hypothesize that LTF has a preferential effect on upper airway dilating muscle activity relative to thoracic pump muscles and hence it "unloads" the upper airway by reducing upper airway resistance. 3. To investigate the effect of REM sleep on upper airway patency. We hypothesize that pharyngeal patency is preserved during REM sleep both at the retropalatal and retroglossal levels. The mentoring plan will be individualized based on the career stage and objectives. Students will receive a focused curriculum with specific assignments to enhance research interest and nurture critical thinking ability. The mentoring process for pre-doctoral fellows will emphasize specific research skills including public presentation, scientific write up, and scientific debate including understanding the limitations of methodology and extrapolation. The focus in post-doctoral fellows and junior faculty will be to nurture independent research leading to an independent (more aptly called, "interdependent") research program. The work environment is outstanding and the institutional commitment is superb.

描述（由申请人提供）： 该提案的主要目标是为申请人提供受保护的时间，以担任学生、实习生和初级教师的导师。该指导工具将包括两个研究项目，重点关注男性性激素对睡眠期间呼吸的影响以及睡眠期间长期促进的决定因素。该研究计划的重点是男性性激素对睡眠期间呼吸的影响。具体目标是： 1. 调查人类睡眠中 LTF 的发生及其决定因素。我们假设睡眠中的人，尤其是打鼾和吸气流量受限的受试者，反复缺氧可以激活 LTF。 2. 确定 LTF 是否会导致咽部口径增加和吸气流量受限改善。我们假设，相对于胸泵肌，LTF 对上气道扩张肌肉活动具有优先作用，因此它通过降低上气道阻力来“卸载”上气道。 3. 探讨快速眼动睡眠对上呼吸道通畅的影响。我们假设在快速眼动睡眠期间，腭后和舌后水平的咽部通畅得以保留。指导计划将根据职业阶段和目标进行个性化。学生将接受有针对性的课程和具体作业，以提高研究兴趣并培养批判性思维能力。博士前研究员的指导过程将强调具体的研究技能，包括公开演讲、科学写作和科学辩论，包括理解方法论和外推法的局限性。博士后研究员和初级教师的重点将是培养独立研究，从而形成独立（更恰当地称为“相互依赖”）的研究项目。工作环境非常出色，制度承诺也非常出色。

项目成果

The impact of obesity on cardiac dysfunction in patients with sleep-disordered breathing.

肥胖对睡眠呼吸障碍患者心功能障碍的影响。

• DOI: 10.1007/s11325-013-0861-0
• 发表时间: 2014
• 期刊: Sleep & breathing = Schlaf & Atmung
• 作者: Alkatib,Shatha;Sankri-Tarbichi,AbdulGhani;Badr,MSafwan
• 通讯作者: Badr,MSafwan

Effect of episodic hypoxia on upper airway mechanics in humans during NREM sleep.

间歇性缺氧对 NREM 睡眠期间人类上气道力学的影响。

• DOI: 10.1152/japplphysiol.00938.2001
• 发表时间: 2002
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Shkoukani,Mahdi;Babcock,MarkA;Badr,MSafwan
• 通讯作者: Badr,MSafwan

Central sleep apnoea

中枢性睡眠呼吸暂停

• DOI: 10.1183/9781849840798.010018
• 发表时间: 2019
• 期刊: ERS Handbook Respiratory Medicine
• 作者: K. Bloch;T. Brack
• 通讯作者: T. Brack

Effects of clonidine on breathing during sleep and susceptibility to central apnoea.

可乐定对睡眠期间呼吸和中枢性呼吸暂停易感性的影响。

• DOI: 10.1016/j.resp.2012.09.005
• 发表时间: 2013
• 期刊: Respiratory physiology & neurobiology
• 影响因子: 2.3
• 作者: Sankri-Tarbichi,AbdulGhani;Grullon,Kevin;Badr,MSafwan
• 通讯作者: Badr,MSafwan

Hypocapnia is associated with increased upper airway expiratory resistance during sleep.

• DOI: 10.1016/j.resp.2011.04.004
• 发表时间: 2011-07-31
• 期刊: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
• 影响因子: 2.3
• 作者: Sankri-Tarbichi, Abdul Ghani;Richardson, Nekeyua N.;Chowdhuri, Susmita;Rowley, James A.;Badr, M. Safwan
• 通讯作者: Badr, M. Safwan