Graphene-FeCo Nanocrystals for Highly Sensitive MRI, Cancer Imaging and Therapy

用于高灵敏度 MRI、癌症成像和治疗的石墨烯-FeCo 纳米晶体

• 批准号: 7454105
• 负责人: Hongjie Dai
• 金额: $ 20.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7454105
• 关键词: Alloys; Animals; Antineoplastic Agents; Area; Biocompatible Materials; Biological; Biology; Blood Circulation; Blood Circulation Time; Caliber; Carbon; Carbon Nanotubes; Chemistry; Chemistry, Other; Clinic; Clinical; Cobalt; Contrast Media; Development; Diagnosis; Disease; Dose; Drug Delivery Systems; Drug Kinetics; Drug usage; Electron Microscopy; Encapsulated; Environment; Exhibits; Fever; Figs - dietary; Fullerenes; Generations; Glean; Heating; Hour; Image; Image Enhancement; Imaging Device; In Vitro; Integrins; Iron; Lasers; Ligands; Light; Location; Magnetic Resonance Imaging; Magnetism; Malignant Neoplasms; Measures; Medical; Medical Imaging; Medical Research; Medicine; Methods; Mind; Modeling; Monitor; Nanotechnology; Nanotubes; Neoplasm Metastasis; Numbers; Peptides; Pharmaceutical Preparations; Phospholipids; Polymers; Process; Property; Proteins; Public Health; RGD (sequence); Reaction; Regulatory Element; Resistance; Resolution; Reticuloendothelial System; Site; Structure; Surface; Suspension substance; Suspensions; Therapeutic Agents; Time; Tumor Angiogenesis; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factors; Vascular remodeling; angiogenesis; anticancer research; base; biomaterial compatibility; cancer imaging; cancer therapy; day; dosage; drug development; functional group; hyperthermia treatment; image guided therapy; improved; in vivo; innovation; iron oxide; irradiation; mouse model; nanocrystal; nanoparticle; neoplastic cell; novel; oxidation; prevent; response; self assembly; subcutaneous; targeted delivery; tool; tumor; tumor progression; uptake

DESCRIPTION (provided by applicant): Magnetic Resonance Imaging (MRI) is one of the most widely used imaging tools in medicine for understanding, treating and preventing diseases. The limitations of MRI include low sensitivity and resolution. The sensitivity of existing contrast agents based on Gd and iron oxide nanoparticles remains insufficient. Innovations are needed to develop new, potent contrast agents to enhance the sensitivity and thus capability of MRI in medical research and clinic. Crystalline iron-cobalt (FeCo) alloy exhibits the highest saturation magnetization among all materials, but has not been used for biological and medical applications thus far due to various materials limitations. This application will develop FeCo nanocrystals encapsulated by a single- layer of carbon grapheme into a new, advanced material for MRI. The single-shell grapheme coating protects the FeCo core from degradation and imparts high biocompatibility. The highly magnetic FeCo core affords superior magnetic relativities to conventional agents for MRI. Overall, this application aims to fully develop grapheme-FeCo nanocrystals into a new MRI contrast agent with unprecedented sensitivity, long blood circulation and specific targeting ability. MRI with high spatial resolution down to ~25<m will be developed and combined with the grapheme-FeCo contrast material. The target specific, long circulating and highly sensitive nanocrystals combined with high resolution MRI will then by used for imaging of tumor, angiogenesis and cancer therapy in animals by drug delivery and grapheme hyperthermia monitoring by MRI. Innovations of the application include new nanotechnology approach to biocompatible materials with advanced properties and new grapheme functionalization methods for dense and branched PEGylation and long circulation. The large surface areas of grapheme shells will be exploited to load great numbers of cancer drugs and targeting ligands for delivery to tumor targets monitored by MRI. The grapheme shell will also be used convert near infrared light into thermal energy for hyperthermic treatment of tumors. High resolution MRI enhanced by highly sensitive and long circulating contrast agent will greatly improves the ability of MRI of cancer angiogenesis for understanding cancer progression, metastasis and response to treatment. Thus, this project will develop a new contrast agent that can improve the capabilities of MRI in all areas of medicine. It will also be applied to cancer research to glean tumor structures and angiogenesis, and to develop new cancer therapy. PUBLIC HEALTH RELEVANCE This project will apply the principles of nanotechnology to develop a new type of magnetic nanocrystals for both high resolution MRI for cancer imaging and MRI monitored delivery of anti- cancer drugs to tumors. These technological advances will provide doctors with both a greater understanding of cancer and more powerful tools for its treatment.

描述（申请人提供）：磁共振成像（MRI）是医学上应用最广泛的成像工具之一，用于了解、治疗和预防疾病。MRI的局限性包括低灵敏度和低分辨率。现有的Gd和氧化铁纳米颗粒造影剂的灵敏度仍然不足。需要创新来开发新的、强效的造影剂，以提高MRI在医学研究和临床中的灵敏度和能力。