Graphene-FeCo Nanocrystals for Highly Sensitive MRI, Cancer Imaging and Therapy

用于高灵敏度 MRI、癌症成像和治疗的石墨烯-FeCo 纳米晶体

• 批准号: 7572823
• 负责人: Hongjie Dai
• 金额: $ 17.05万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7572823
• 关键词: Alloys; Animals; Antineoplastic Agents; Area; Biocompatible Materials; Biological; Biology; Blood Circulation; Blood Circulation Time; Caliber; Carbon; Carbon Nanotubes; Chemistry; Clinic; Clinical; Cobalt; Contrast Media; Development; Disease; Dose; Drug Delivery Systems; Drug Kinetics; Drug usage; Electron Microscopy; Encapsulated; Environment; Exhibits; Fever; Figs - dietary; Fullerenes; Generations; Glean; Heating; Hour; Image; Image Enhancement; Imaging Device; In Vitro; Integrins; Iron; Lasers; Ligands; Light; Location; Magnetic Resonance Imaging; Magnetism; Malignant Neoplasms; Measures; Medical; Medical Imaging; Medical Research; Medicine; Methods; Mind; Modeling; Monitor; Nanotechnology; Neoplasm Metastasis; Peptides; Pharmaceutical Preparations; Phospholipids; Polymers; Process; Property; Proteins; RGD (sequence); Reaction; Regulatory Element; Resistance; Resolution; Reticuloendothelial System; Site; Structure; Surface; Suspension substance; Suspensions; Therapeutic Agents; Time; Tumor Angiogenesis; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factors; Vascular remodeling; angiogenesis; anticancer research; base; biomaterial compatibility; cancer imaging; cancer therapy; disease diagnosis; dosage; drug development; functional group; image guided therapy; improved; in vivo; innovation; iron oxide; irradiation; mouse model; nanocrystal; nanoparticle; neoplastic cell; novel; oxidation; prevent; public health relevance; response; self assembly; subcutaneous; targeted delivery; tool; tumor; tumor progression; uptake

DESCRIPTION (provided by applicant): Magnetic Resonance Imaging (MRI) is one of the most widely used imaging tools in medicine for understanding, treating and preventing diseases. The limitations of MRI include low sensitivity and resolution. The sensitivity of existing contrast agents based on Gd and iron oxide nanoparticles remains insufficient. Innovations are needed to develop new, potent contrast agents to enhance the sensitivity and thus capability of MRI in medical research and clinic. Crystalline iron-cobalt (FeCo) alloy exhibits the highest saturation magnetization among all materials, but has not been used for biological and medical applications thus far due to various materials limitations. This application will develop FeCo nanocrystals encapsulated by a single- layer of carbon grapheme into a new, advanced material for MRI. The single-shell grapheme coating protects the FeCo core from degradation and imparts high biocompatibility. The highly magnetic FeCo core affords superior magnetic relativities to conventional agents for MRI. Overall, this application aims to fully develop grapheme-FeCo nanocrystals into a new MRI contrast agent with unprecedented sensitivity, long blood circulation and specific targeting ability. MRI with high spatial resolution down to ~25<m will be developed and combined with the grapheme-FeCo contrast material. The target specific, long circulating and highly sensitive nanocrystals combined with high resolution MRI will then by used for imaging of tumor, angiogenesis and cancer therapy in animals by drug delivery and grapheme hyperthermia monitoring by MRI. Innovations of the application include new nanotechnology approach to biocompatible materials with advanced properties and new grapheme functionalization methods for dense and branched PEGylation and long circulation. The large surface areas of grapheme shells will be exploited to load great numbers of cancer drugs and targeting ligands for delivery to tumor targets monitored by MRI. The grapheme shell will also be used convert near infrared light into thermal energy for hyperthermic treatment of tumors. High resolution MRI enhanced by highly sensitive and long circulating contrast agent will greatly improves the ability of MRI of cancer angiogenesis for understanding cancer progression, metastasis and response to treatment. Thus, this project will develop a new contrast agent that can improve the capabilities of MRI in all areas of medicine. It will also be applied to cancer research to glean tumor structures and angiogenesis, and to develop new cancer therapy. PUBLIC HEALTH RELEVANCE This project will apply the principles of nanotechnology to develop a new type of magnetic nanocrystals for both high resolution MRI for cancer imaging and MRI monitored delivery of anti- cancer drugs to tumors. These technological advances will provide doctors with both a greater understanding of cancer and more powerful tools for its treatment.

描述（由申请人提供）： 磁共振成像（MRI）是医学中用于了解、治疗和预防疾病最广泛使用的成像工具之一。 MRI 的局限性包括灵敏度和分辨率较低。现有基于 Gd 和氧化铁纳米颗粒的造影剂的灵敏度仍然不足。需要创新来开发新的、有效的造影剂，以提高 MRI 在医学研究和临床中的灵敏度和能力。 晶体铁钴（FeCo）合金在所有材料中表现出最高的饱和磁化强度，但由于各种材料的限制，迄今为止尚未用于生物和医学应用。该应用将把单层碳石墨烯封装的 FeCo 纳米晶体开发成一种用于 MRI 的新型先进材料。单壳石墨烯涂层可保护 FeCo 核心免遭降解并赋予高生物相容性。高磁性 FeCo 核心为 MRI 提供了优于传统试剂的磁相对论。 总体而言，该应用旨在将石墨烯-FeCo纳米晶充分开发成具有前所未有的灵敏度、长血循环和特异性靶向能力的新型MRI造影剂。将开发具有低至 ~25<m 的高空间分辨率的 MRI，并将其与石墨烯-FeCo 对比材料相结合。目标特异性、长循环和高度敏感的纳米晶体与高分辨率 MRI 相结合，将用于通过药物输送和 MRI 监测石墨烯高温对动物进行肿瘤、血管生成和癌症治疗的成像。 该应用的创新包括具有先进特性的生物相容性材料的新纳米技术方法以及用于致密和支链聚乙二醇化和长循环的新石墨烯功能化方法。石墨烯壳的大表面积将被用来装载大量抗癌药物和靶向配体，以输送到 MRI 监测的肿瘤靶点。石墨烯壳还将用于将近红外光转化为热能，用于肿瘤的高温治疗。高灵敏度、长循环造影剂增强的高分辨率MRI将大大提高MRI对癌症血管生成的了解能力，以了解癌症的进展、转移和治疗反应。 因此，该项目将开发一种新的造影剂，可以提高 MRI 在所有医学领域的能力。它还将应用于癌症研究，以收集肿瘤结构和血管生成，并开发新的癌症疗法。 公共健康相关性 该项目将应用纳米技术原理开发一种新型磁性纳米晶体，用于癌症成像的高分辨率 MRI 和 MRI 监测的抗癌药物向肿瘤的输送。这些技术进步将使医生对癌症有更深入的了解，并提供更强大的治疗工具。

项目成果

Separation of nanoparticles in a density gradient: FeCo@C and gold nanocrystals.

• DOI: 10.1002/anie.200805047
• 发表时间: 2009
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Sun, Xiaoming;Tabakman, Scott M.;Seo, Won-Seok;Zhang, Li;Zhang, Guangyu;Sherlock, Sarah;Bai, Lu;Dai, Hongjie
• 通讯作者: Dai, Hongjie

Photothermally enhanced drug delivery by ultrasmall multifunctional FeCo/graphitic shell nanocrystals.

• DOI: 10.1021/nn103415x
• 发表时间: 2011-02-22
• 期刊: ACS nano
• 影响因子: 17.1
• 作者: Sherlock SP;Tabakman SM;Xie L;Dai H
• 通讯作者: Dai H