Graphene-FeCo Nanocrystals for Highly Sensitive MRI, Cancer Imaging and Therapy

用于高灵敏度 MRI、癌症成像和治疗的石墨烯-FeCo 纳米晶体

• 批准号: 7572823
• 负责人: Hongjie Dai
• 金额: $ 17.05万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7572823
• 关键词: Alloys; Animals; Antineoplastic Agents; Area; Biocompatible Materials; Biological; Biology; Blood Circulation; Blood Circulation Time; Caliber; Carbon; Carbon Nanotubes; Chemistry; Clinic; Clinical; Cobalt; Contrast Media; Development; Disease; Dose; Drug Delivery Systems; Drug Kinetics; Drug usage; Electron Microscopy; Encapsulated; Environment; Exhibits; Fever; Figs - dietary; Fullerenes; Generations; Glean; Heating; Hour; Image; Image Enhancement; Imaging Device; In Vitro; Integrins; Iron; Lasers; Ligands; Light; Location; Magnetic Resonance Imaging; Magnetism; Malignant Neoplasms; Measures; Medical; Medical Imaging; Medical Research; Medicine; Methods; Mind; Modeling; Monitor; Nanotechnology; Neoplasm Metastasis; Peptides; Pharmaceutical Preparations; Phospholipids; Polymers; Process; Property; Proteins; RGD (sequence); Reaction; Regulatory Element; Resistance; Resolution; Reticuloendothelial System; Site; Structure; Surface; Suspension substance; Suspensions; Therapeutic Agents; Time; Tumor Angiogenesis; Vascular Endothelial Growth Factor Receptor; Vascular Endothelial Growth Factors; Vascular remodeling; angiogenesis; anticancer research; base; biomaterial compatibility; cancer imaging; cancer therapy; disease diagnosis; dosage; drug development; functional group; image guided therapy; improved; in vivo; innovation; iron oxide; irradiation; mouse model; nanocrystal; nanoparticle; neoplastic cell; novel; oxidation; prevent; public health relevance; response; self assembly; subcutaneous; targeted delivery; tool; tumor; tumor progression; uptake

DESCRIPTION (provided by applicant): Magnetic Resonance Imaging (MRI) is one of the most widely used imaging tools in medicine for understanding, treating and preventing diseases. The limitations of MRI include low sensitivity and resolution. The sensitivity of existing contrast agents based on Gd and iron oxide nanoparticles remains insufficient. Innovations are needed to develop new, potent contrast agents to enhance the sensitivity and thus capability of MRI in medical research and clinic. Crystalline iron-cobalt (FeCo) alloy exhibits the highest saturation magnetization among all materials, but has not been used for biological and medical applications thus far due to various materials limitations. This application will develop FeCo nanocrystals encapsulated by a single- layer of carbon grapheme into a new, advanced material for MRI. The single-shell grapheme coating protects the FeCo core from degradation and imparts high biocompatibility. The highly magnetic FeCo core affords superior magnetic relativities to conventional agents for MRI. Overall, this application aims to fully develop grapheme-FeCo nanocrystals into a new MRI contrast agent with unprecedented sensitivity, long blood circulation and specific targeting ability. MRI with high spatial resolution down to ~25<m will be developed and combined with the grapheme-FeCo contrast material. The target specific, long circulating and highly sensitive nanocrystals combined with high resolution MRI will then by used for imaging of tumor, angiogenesis and cancer therapy in animals by drug delivery and grapheme hyperthermia monitoring by MRI. Innovations of the application include new nanotechnology approach to biocompatible materials with advanced properties and new grapheme functionalization methods for dense and branched PEGylation and long circulation. The large surface areas of grapheme shells will be exploited to load great numbers of cancer drugs and targeting ligands for delivery to tumor targets monitored by MRI. The grapheme shell will also be used convert near infrared light into thermal energy for hyperthermic treatment of tumors. High resolution MRI enhanced by highly sensitive and long circulating contrast agent will greatly improves the ability of MRI of cancer angiogenesis for understanding cancer progression, metastasis and response to treatment. Thus, this project will develop a new contrast agent that can improve the capabilities of MRI in all areas of medicine. It will also be applied to cancer research to glean tumor structures and angiogenesis, and to develop new cancer therapy. PUBLIC HEALTH RELEVANCE This project will apply the principles of nanotechnology to develop a new type of magnetic nanocrystals for both high resolution MRI for cancer imaging and MRI monitored delivery of anti- cancer drugs to tumors. These technological advances will provide doctors with both a greater understanding of cancer and more powerful tools for its treatment.

描述（由申请人提供）：磁共振成像（MRI）是用于理解，治疗和预防疾病的医学中使用最广泛的成像工具之一。 MRI的局限性包括低灵敏度和分辨率。基于GD和氧化铁纳米颗粒的现有对比剂的敏感性仍然不足。需要创新来开发新的，有效的对比剂，以增强MRI在医学研究和诊所中的敏感性，从而能力。 结晶铁铜（FECO）合金在所有材料中均表现出最高的饱和度磁化，但由于各种材料的限制，迄今为止尚未用于生物和医疗应用。该应用将开发由单层碳素封装成的FECO纳米晶体，以作为MRI的新高级材料。单壳石素涂层可保护FECO芯免受降解，并赋予高生物相容性。高度磁性的FECO芯为MRI的常规代理提供了优异的磁相对率。 总体而言，该应用程序旨在将素纳米晶体完全开发为具有前所未有的灵敏度，长血液循环和特定靶向能力的新的MRI对比剂。高空间分辨率降至〜25 <m的MRI将开发并与素素 - feco对比材料结合使用。然后，通过药物递送和MRI的墨西米高温监测，将使用靶标特异性，长循环和高度敏感的纳米晶体与高分辨率MRI结合使用。 该应用程序的创新包括具有先进特性的生物相容性材料的新型纳米技术方法，以及用于致密和分支的新晶格函数化方法，用于致密和分支的pegylation和长循环。墨壳的大表面积将被利用，以加载大量癌症药物，并靶向配体以递送到MRI监测的肿瘤靶标。石素外壳还将用于近红外光转换为热能，以对肿瘤进行过度热治疗。高分辨率MRI通过高度敏感和长期循环造影剂增强，将大大提高癌症血管生成的MRI了解癌症进展，转移和对治疗的反应的能力。 因此，该项目将开发一种新的对比剂，可以提高MRI在所有医学领域的能力。它也将应用于癌症研究中，以收集肿瘤结构和血管生成，并开发新的癌症治疗。 公共卫生相关性该项目将采用纳米技术的原理来开发一种用于癌症成像的高分辨率MRI的新型磁性纳米晶体，并且MRI监测了抗癌药物向肿瘤的递送。这些技术进步将为医生提供对癌症和更强大的治疗工具的更多了解。

项目成果

Separation of nanoparticles in a density gradient: FeCo@C and gold nanocrystals.

• DOI: 10.1002/anie.200805047
• 发表时间: 2009
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Sun, Xiaoming;Tabakman, Scott M.;Seo, Won-Seok;Zhang, Li;Zhang, Guangyu;Sherlock, Sarah;Bai, Lu;Dai, Hongjie
• 通讯作者: Dai, Hongjie

Photothermally enhanced drug delivery by ultrasmall multifunctional FeCo/graphitic shell nanocrystals.

• DOI: 10.1021/nn103415x
• 发表时间: 2011-02-22
• 期刊: ACS nano
• 影响因子: 17.1
• 作者: Sherlock SP;Tabakman SM;Xie L;Dai H
• 通讯作者: Dai H