Multi-level modelling of mitochondrial energy metabolism

线粒体能量代谢的多层次建模

• 批准号: BB/F005431/1
• 负责人: David Fell
• 金额: $ 31.88万
• 依托单位: Oxford Brookes University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FF005431%2F1
• 关键词: Multi; level; modelling; mitochondrial; energy

The cells that make up our bodies themselves contain smaller structures that carry out specific tasks in the cell. The mitochondria are one of these components, and they are the main site in the cell where the oxygen that we breathe is used and the carbon dioxide is produced. As part of this process they generate most of the cell's energy and send it out in the form of the chemical ATP for the rest of the cell to use. It is possible to isolate working mitochondria from cells and to study them in the laboratory, so we know a lot about what substances they take up from the cell and how they are used in energy production. Mitochondria can also be taken apart, and we now have detailed knowledge of the components they are built from and the enzymes that bring about the energy production. What remains difficult is building a detailed description of how mitochondria work in the cell from all these isolated bits and pieces. The purpose of this project is to make computer models that will help us to do this. Understanding how mitochondria work is important in itself, but they can develop faults that cause a number of diseases, so the models will also help to understand these diseases better, and maybe help to design treatments.

构成我们身体的细胞本身包含较小的结构，在细胞中执行特定的任务。线粒体是这些成分之一，它们是细胞中使用我们呼吸的氧气和产生二氧化碳的主要位置。作为这个过程的一部分，它们产生细胞的大部分能量，并以化学物质三磷酸腺苷的形式发送出去，供细胞的其余部分使用。从细胞中分离出正在工作的线粒体并在实验室进行研究是可能的，所以我们对它们从细胞中摄取什么物质以及它们如何用于能源生产有很多了解。线粒体也可以拆分，我们现在对线粒体的组成成分和产生能量的酶有了详细的了解。仍然很难的是从所有这些孤立的片段中构建线粒体如何在细胞中工作的详细描述。这个项目的目的是制作计算机模型，帮助我们做到这一点。了解线粒体是如何工作的本身很重要，但它们可能会出现导致许多疾病的缺陷，因此这些模型也将有助于更好地了解这些疾病，或许还有助于设计治疗方法。