PERIODONTAL DISEASE

牙周疾病

• 批准号: 7609599
• 负责人: LYNNAE Karen MILLAR Sauvage
• 金额: $ 1.57万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7609599
• 关键词: Asians; Case-Control Studies; Child; Computer Retrieval of Information on Scientific Projects Database; Data; Diabetes Mellitus; Enrollment; Funding; Grant; Hawaii; Hawaiian population; Hemorrhage; Institution; Measures; Medical center; Numbers; Odds Ratio; Pacific Island Americans; Patient currently pregnant; Patients; Periodontal Diseases; Periodontal Pocket; Pilot Projects; Population; Pregnant Women; Premature Birth; Rate; Research; Research Personnel; Resources; Risk; Risk Factors; Site; Source; Subgroup; Term Birth; Time; Tooth structure; United States National Institutes of Health; Woman; diabetic; non-diabetic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To conduct a small case-control study to determine the extent of periodontal disease in Asian and Pacific Islander diabetic and non-diabetic women who have term and pre-term babies. This pilot study is ongoing at Kapiolani Medical Center for Women and Children, and to date, we have enrolled 200 patients. Preliminary analysis indicates that periodontal disease measures do differ among the four subgroups in the study. The four groups have a similar number of teeth at risk for periodontal disease. Preterm diabetics have significantly more periodontal pockets than both term and preterm non-diabetics. Preterm diabetics have significantly more sites with attachment loss of ? 3mm, and more sites that bleed after probing than term non-diabetic subjects. Finally when compared to term births in non-diabetic women, diabetic women with preterm births have 6.0 times the odds of having moderate to severe periodontal disease. Similarly, diabetic women with term babies had 4.0 times the odds of having moderate to severe periodontal disease, and non-diabetic women had 2.9 times the odds. While these odds ratios are unadjusted for established risk factors for preterm birth, analyses in other populations indicated little confounding was present and the odds ratios remained significant. The preliminary data suggests diabetic Asian and Pacific Islander pregnant women have a high rate of periodontal disease. The rate of periodontal disease was higher in women delivering preterm compared to women delivering at term. Preterm diabetics had the highest rate of periodontal disease when compared to term diabetics, term non-diabetics and preterm non-diabetics. Periodontal disease may be a potentially modifiable and treatable cause of preterm birth, and it seems to occur at a particularly high rate amongst pregnant diabetics. This is important to our population here in Hawaii as we have a high rate of diabetes, particularly among the Native Hawaiian population.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：进行一项小型病例对照研究，以确定具有期限和期前婴儿的亚洲和太平洋岛民糖尿病和非糖尿病妇女的牙周疾病程度。 这项试点研究正在Kapiolani医学中心针对妇女和儿童进行，迄今为止，我们已经招募了200名患者。初步分析表明，研究中四个亚组的牙周疾病措施确实有所不同。这四组具有类似数量的牙齿牙齿的牙齿。早产糖尿病患者的牙周口袋明显多于术语和早产非糖尿病患者。早产糖尿病患者有更多的地点，而依恋丧失？ 3mm，探测后流血的位点要比术语非糖尿病受试者流血。最终，与非糖尿病妇女的期限分娩相比，早产妇女的糖尿病女性的6.0倍，是中度至重度牙周疾病的几率。同样，患有婴儿的糖尿病妇女的牙周疾病的几率是4.0倍，而非糖尿病妇女的几率是2.9倍。尽管这些赔率比对早产的既定风险因素进行了调整，但其他人群的分析表明，几乎没有混淆，几率比率仍然显着。初步数据表明糖尿病亚洲和太平洋岛民孕妇患有牙周疾病率很高。与任期交付的女性相比，交付早产的女性的牙周疾病率更高。与期限糖尿病患者相比，早产糖尿病患者的牙周疾病发生率最高。牙周疾病可能是早产的潜在可修改和可治疗的原因，并且在怀孕的糖尿病患者中似乎以特别高的速度发生。这对我们在夏威夷的人口很重要，因为我们的糖尿病率很高，尤其是在夏威夷本地人口中。