PHENOTYPING CORE

表型核心

• 批准号: 7960424
• 负责人: LYNNAE Karen MILLAR Sauvage
• 金额: $ 11.38万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960424
• 关键词: Age-Years; Archives; Blood specimen; Cheek structure; Child; Clinical Data; Clinical Investigator; Clinical Research; Collection; Computer Retrieval of Information on Scientific Projects Database; Consent; Data; Databases; Discipline of obstetrics; Enrollment; Exclusion; Funding; Future; Grant; Health; High-Risk Pregnancy; Human Development; Human Resources; Imprisonment; Inpatients; Institution; Laboratories; Laboratory Research; Measurement; Medical center; Midwife; Neonatal; Pathology; Patients; Perinatal; Phenotype; Physical Examination; Physicians; Placenta; Procedures; Process; Protocols documentation; Reading; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Subjects; Resources; Sampling; Source; Specimen; Swab; Techniques; Tissue Sample; Tissues; Umbilical Cord Blood; United States National Institutes of Health; Woman; clinical phenotype; follow-up; human subject; improved; neonate; pregnant; repository; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Clinical Phenotype/Patient Sample Core will streamline access to clinical data and patient samples for the Pacific Research Center for Early Human Development (PRCEHD) investigators and other clinical investigators at JABSOM. The clinical phenotyping component of the Core consists of a new perinatal/neonatal database, a new placental bank, and the option for a standardized neonatal examination and improved neonatal follow-up capability. The patient sample component of this Core will provide ascertainment and recruitment of potential research subjects, ongoing collection of relevant specimens, efficient protocols to provide specimens and accompanying clinical data (as necessary) to investigators, and storage of materials in a sample repository. Finally, the core laboratory will offer basic and advanced pathology techniques to current and future projects. The specific aims of this Core are: 1) to build a new research database focused on perinatal and neonatal conditions, 2) to bank placental data and samples for all high-risk pregnancies for which standard pathological examinations were not requested by the attending physician or midwife, 3) to provide consistent and detailed physical examinations and anthropomorphic measurements on selected neonates, 4) to collect, access, archive, and distribute to the CCRE investigators high-quality tissue and blood specimens and relevant clinical data from obstetric and neonatal patients. This request for CRC personnel and facilities support is limited to the implementation of specific aim 4) (as listed above). The Core does not directly involve human subjects in experiments. The objective of this Core is to recruit all women delivering at Kapi'olani Medical Center for Women and Children (KMCWC). The Clinical Research Center's (CRC's) involvement in the study includes the collection of maternal blood samples or cheek swabs (similar to a Q-tip), cord blood samples, and placentas; and the transporting of these tissues to the JABSOM Clinical Phenotype/ Patient Sample Core Lab. All tissue samples and personal information will be securely maintained at the JABSOM Clinical Phenotype/Patient Sample Core laboratory for research use. All potential subjects will be pregnant, or recently delivered, inpatients at Kapi'olani Medical Center for Women and Children. The subjects will be 18-50 years of age, and will be able to read, speak and understand English. We will not include incarcerated women in this study. All subjects will be enrolled and consented prior to the collection of their personal health information and biomedical tissues. All subjects will be mentally competent to understand the consent process and the study procedures. There are no ethnic exclusions in this study. A record of ethnic background will be part of the patient database so that this factor can be analyzed.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 临床表型/患者样品核心将简化太平洋早期人类发展中心（PRCEHD）研究人员和JABSOM的其他临床研究人员的临床数据和患者样本的访问。 核心的临床表型成分包括一个新的围产期/新生儿数据库，一个新的胎盘库，以及标准化的新生儿检查和改善新生儿随访能力的选项。 该核心的患者样本部分将提供潜在研究对象的确定和募集，持续收集相关标本，有效的方案，以向研究者提供标本和随附的临床数据（必要）以及样品存储库中的材料的存储。 最后，核心实验室将为当前和将来的项目提供基本和先进的病理技术。 The specific aims of this Core are: 1) to build a new research database focused on perinatal and neonatal conditions, 2) to bank placental data and samples for all high-risk pregnancies for which standard pathological examinations were not requested by the attending physician or midwife, 3) to provide consistent and detailed physical examinations and anthropomorphic measurements on selected neonates, 4) to collect, access, archive, and distribute对于CCRE研究者，来自产科和新生儿患者的高质量组织和血液标本以及相关的临床数据。 此要求CRC人员和设施支持的要求仅限于实施特定目标4）（如上所述）。 核心不直接涉及人类受试者。 该核心的目的是招募在Kapi'olani妇女和儿童医疗中心（KMCWC）招募所有妇女。 临床研究中心（CRC）参与研究中的参与包括收集母体血液样本或脸颊拭子（类似于Q-TIP），脐带血样本和胎盘；以及将这些组织运输到JABSOM临床表型/患者样品核心实验室。 所有组织样本和个人信息将均可在JABSOM临床表型/患者样品核心实验室进行研究。 所有潜在的受试者将怀孕或最近在Kapi'olani妇女和儿童医疗中心接受住院患者。受试者将年满18-50岁，并能够阅读，说和理解英语。在这项研究中，我们不会包括被监禁的妇女。在收集其个人健康信息和生物医学组织之前，所有受试者都将被纳入和同意。 所有受试者将在精神上有能力了解同意过程和研究程序。 这项研究没有种族排除。 种族背景的记录将是患者数据库的一部分，以便可以分析此因素。