Helicobacter pylori VacA toxin: modulation of human mitochondrial function by a bacterial pathogen

幽门螺杆菌 VacA 毒素：细菌病原体对人类线粒体功能的调节

• 批准号: nhmrc : 1010745
• 负责人: Dr Kip Gabriel
• 金额: $ 33.87万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/helicobacter-pylori-vaca-bacterial-pathogen/109524
• 关键词: Helicobacter; pylori; VacA; toxin; modulation

This work will greatly further our understanding of how a bacterium, Helicobacter pylori, causes stomach ulcers and cancer. We will use cutting edge model systems to study the VacA toxin that is secreted from the bacteria and is targeted to human cells. We will examine where the toxin goes and how it affects our cells. It is expected that the improved understanding that will arise from this work will assist researchers to better devise drugs against this prevalent pathogen.

这项工作将大大加深我们对幽门螺杆菌如何导致胃溃疡和癌症的理解。我们将使用最先进的模型系统来研究从细菌中分泌并靶向人类细胞的VacA毒素。我们将检查毒素的去向以及它如何影响我们的细胞。预计这项工作所产生的更好的理解将有助于研究人员更好地设计针对这种流行病原体的药物。