Helicobacter pylori VacA toxin: modulation of human mitochondrial function by a bacterial pathogen

这项工作将大大加深我们对幽门螺杆菌是如何引起胃溃疡和癌症的理解。我们将使用最先进的模型系统来研究VacA毒素，这种毒素是由细菌分泌的，并针对人类细胞。我们将检查毒素的去向以及它如何影响我们的细胞。期望从这项工作中得到的更好的理解将有助于研究人员更好地设计针对这种流行病原体的药物。

This work will greatly further our understanding of how a bacterium, Helicobacter pylori, causes stomach ulcers and cancer. We will use cutting edge model systems to study the VacA toxin that is secreted from the bacteria and is targeted to human cells. We will examine where the toxin goes and how it affects our cells. It is expected that the improved understanding that will arise from this work will assist researchers to better devise drugs against this prevalent pathogen.