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Temperature-activated TRP channels and thermosensation

温度激活的 TRP 通道和热感觉

基本信息

批准号：
7405993
负责人：
Ardem Patapoutian
金额：
$ 41.55万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-04-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7405993
关键词：
Acute Address Afferent Neurons Behavioral Behavioral Assay Biochemical Genetics Biological Assay Camphor Capsaicin Cells Chemicals Chromosome Pairing Code Data Engineering Epidermis Esthesia Genes Goals Hearing Heating Homologous Gene Investigation Ion Channel Knock-out Knockout Mice Link Mechanics Mediating Modality Molecular Mus Nerve Nerve Endings Nerve Fibers Nervous system structure Neurites Neurobiology Neurons Nociception Other Finding Pain Pathway interactions Phenotype Physiological Play Population Protein Overexpression Proteins Publications Publishing Recurrent pain Research Personnel Role Sensory Sensory Receptors Signal Transduction Skin Skin Temperature Stimulus Synapses System TRPV channel TRPV1 gene Taste Perception Temperature Temperature Sense Testing Thermal Hyperalgesias Thinking Tissues Touch sensation Transgenic Mice Vision Work base design femoral nerve in vivo keratinocyte preference promoter receptor research study response tool warm temperature

项目摘要

Recent years have seen great advances in the molecular description of sensory neurobiology. Of the five popularly characterized senses - sight, hearing, taste, smeli, and touch - touch is among the most varied and perhaps least understood. Within this modality is the ability to sense mechanical forces, chemical stimuli, and temperature, and the molecules that mediate this ability have been a long-standing mystery. My group and others have recently discovered ion channels that are activated by different thresholds of temperature, and might enable sensory neurons to convey temperature information. Among these ion channels is TRPV3, which senses warm temperatures and is expressed in the skin. Here we use genetic and biochemical tools to test if TRPV3 and its close homologs play an essential role in thermosensation and pain.

近年来，在感觉神经生物学的分子描述方面取得了很大进展。在五种常见的感官--视觉、听觉、味觉、嗅觉和触觉--中，触觉是变化最大的，也是人们最不了解的。在这种形态中，机械力、化学刺激和温度，以及介导这种能力的分子一直是个谜我的团队和其他人最近发现了离子通道它们被不同的温度阈值激活，可能使感觉神经元能够传递温度信息。在这些离子通道中有TRPV 3，温度，并在皮肤中表达。在这里，我们使用遗传和生物化学工具来测试， TRPV 3及其同源物在热感觉和疼痛中起重要作用。