FOLLOWING THE FATE OF HCMV GENE PRODUCTS IN HOST CELLS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定是研究者机构。巨细胞病毒在所有地理位置和社会经济群体中广泛传播，并在美国40岁以下的成年人中感染85%。我们的目的是研究人巨细胞病毒衍生物与细胞蛋白的相互作用，这将有助于分析疱疹病毒调控的细胞途径。我们已经分离出蛋白A或GFP标记的HCMV病毒蛋白与它们的宿主和病毒相互作用的合作伙伴在感染的各个阶段。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cytomegalovirus is widely spread throughout all geographic locations and socioeconomic group and infects 85% of adults in United States by 40 years of age. Our aim is to study the interactions of human cytomegalovirus derivatives with cellular proteins, which would give insights towards the analysis of cellular pathways modulated by herpesviruses. We have isolated Protein A- or GFP-tagged HCMV viral proteins with their host and viral interacting partners at various stages of infections.