PROJECT 3

项目3

• 批准号: 7905601
• 负责人: THOMAS E SHENK
• 金额: $ 24.08万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7905601
• 关键词: Area; Biology; Cell Wall; Cells; Collaborations; Cytomegalovirus; Development; Equilibrium; Genetic; Gram-Negative Bacteria; Growth; Human; Infection; Interferons; Isotope Labeling; Kinetics; Malaria; Metabolism; Natural Immunity; Nature; Neurons; Pattern; Peptidoglycan; Production; Suid Herpesvirus 1; System; Technology; Transcriptional Regulation; Viral; Virus; fatty acid biosynthesis; frontier; mathematical model; pathogen; programs; quorum sensing; response; small molecule; virology

PROJECT 3 - HOST-PATHAGEN INTERACTIONS Project Leader: T. Shenk (Molbio) This project is focused on mechanisms intrinsic to the growth and spread of viral, parasitic and bacterial pathogens. Shenk will study mechanisms by which innate immunity limits the replication and spread of human cytomegalovirus, Enquist will explore how pseudorabies virus moves within neurons and spreads between neurons, Llinas will study transcriptional regulation and small molecule metabolism in malaria, Gital/Shaevitz will elucidate the mechanisms by which the peptidoglycan cell wall network of gram-negative bacteria is spatially and temporally organized, and Bassler will study quorum sensing in a variety of bacterial systems.

项目3 -主持人与传道人的互动 项目负责人：T.申克（莫尔比奥） 该项目的重点是病毒、寄生虫和细菌病原体生长和传播的内在机制。Shenk将研究先天免疫限制人类巨细胞病毒复制和传播的机制，Enquist将探索伪狂犬病病毒如何在神经元内移动并在神经元之间传播，Llinas将研究疟疾中的转录调控和小分子代谢，Gital/Shaevitz将阐明革兰氏阴性细菌的肽聚糖细胞壁网络在空间和时间上组织的机制，Bassler将研究各种细菌系统中的群体感应。