Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate

用于干细胞命运机械调节的仿生纳米颗粒

• 批准号: DP240102315
• 负责人: Dr Ruirui Qiao
• 金额: $ 38.91万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102315
• 关键词: Bio; inspired; Nanoparticles; Mechano; Regulation

Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this project include a new fundamental understanding of the effect of mechanical properties on cell function, novel insights into the regulation of stem cell fate, and the development of a new class of roughness-tunable materials suitable for use in tissue engineering and pharmaceutical applications.

机械刺激在调节干细胞命运中起关键作用。纳米结构介导的机械信号可以精确地刺激干细胞，但预测它们对干细胞分化的影响具有挑战性。该项目旨在设计纳米结构来调节干细胞的命运，并对影响细胞功能的机械特性有基本的了解。该项目的预期成果和益处包括对机械性能对细胞功能的影响的新的基本理解，对干细胞命运调节的新见解，以及开发适用于组织工程和制药应用的新型粗糙度可调材料。