BETA CELL CALCIUM INDEPENDENT GROUP VIA PHOSPHOLIPASE A2

通过磷脂酶 A2 形成的 Beta 细胞钙独立组

• 批准号: 7355194
• 负责人: S BAO
• 金额: $ 0.94万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7355194
• 关键词: BETA; CELL; CALCIUM; INDEPENDENT; GROUP

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Evidence that the Group VIA cytosolic calcium-independent phospholipase A2 (iPLA2B) appears to participate in B-cell signal transduction includes the observations that inhibition of iPLA2B with the bromoenol lactone suicide substrate (BEL) suppresses glucose-stimulated insulin secretion and that over expression of iPLA2B amplifies insulin secretory responses in INS-1 insulinoma cell. Arachidonic acid produced by iPLA2B-catalyzed hydrolysis of their substrates induces release of Ca2+ from ER stores, an event thought to participate in glucose-stimulated insulin secretion.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。VIA组细胞溶质钙非依赖性磷脂酶A2（iPLA 2B）似乎参与B细胞信号转导的证据包括用溴烯醇内酯自杀底物（BEL）抑制iPLA 2B抑制葡萄糖刺激的胰岛素分泌以及iPLA 2B的过表达放大INS-1胰岛素瘤细胞中的胰岛素分泌应答的观察结果。通过iPLA 2B催化的底物水解产生的花生四烯酸诱导Ca 2+从ER储存中释放，这是一种被认为参与葡萄糖刺激的胰岛素分泌的事件。