LEUKOTOXIN DIOL FROM CORN COB ANIMAL BEDDING STIMULATES BREAST CANCER CELLS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Ground corncob contains a number of mitogenic agents that stimulate breast and prostate cancer cell proliferation in vitro and in vivo and also disrupt male and female reproductive function and cyclicity. Purification of ground corncob bedding extracts by HPLC revealed a major peak of mitogentic activity eluting from a C8 reversed phase column that contained 9, 10-dihydroxy-12-octadecenoicacid (LTX-diol), a well-known leukotoxin-diol. This mixture of the two positional isomers (LTX-diols) stimulated the proliferation of MCF-7 human breast cancer cells in vitro at concentrations ranging from 13-26 uM. Thus, LTX-diol derived from exogenous or endogenous sources or pathways may promote or enhance malignant cell proliferation that we suspect are endocrine.