Vervet Research Colony as a Biomedical Resource

超出空间 但前提是。 猕猴的严重短缺导致迫切需要开发替代的非人类灵长类动物 生物医学研究的模型。非洲绿猴(ChlorOcean Bus Atheiops)是理想的候选者 来填补这个职位的空缺。Vervets是东半球的猴子，在行为、生理和行为上与恒河猴相似 解剖学。加勒比海衍生的马鞭草很容易买到，而且比恒河猴便宜，而且因为它们确实是这样做的 它们不携带猴疱疹病毒(B病毒)，与恒河猴或其他亚洲人相比，它们对健康和安全的风险更小 猕猴替代品。加州大学洛杉矶分校韦尔韦特研究群体(VRC)是一个成熟的中心，它支持当地 对马尾猴神经生物学、行为和遗传学的研究已有29年，使其具有独特的地位 作为国家级马尾猴资源中心的基础。广泛的遗传和行为 在VRC收集的马鞭草数据库使其成为一种特别有价值的资源，用于在 一些生物医学领域，包括肥胖、糖尿病、老龄化、精神和行为障碍， 以及对心血管疾病的脆弱性。NCRR P40赠款的支持将使VRC能够a)增加 通过培育在美国殖民地出生的无特定病原体的非人类灵长类动物为生物医学研究提供 (SPF)为NIH资助的调查人员提供已知年龄和病史的马鞭草；b)为马鞭草提供特定的 特征和情况(例如，年老、冲动、肥胖、糖尿病)；c)保持 用作研究遗传贡献的国家资源的有血统的、有基因分型的藜类群体 提供有关马鞭草临床护理和管理的培训和信息，以加强 该物种在其他中心的使用，以及e)支持继续使用马鞭草模型进行遗传， 生物行为和神经生物学研究，以及肥胖症研究的新马鞭草模型的开发， 糖尿病和代谢综合征。已经组织了两个核心来实现这些目标。《野兽》 RESOURCES CORE将管理动物护理和繁殖计划，维护群体记录系统， 传播有关长尾猴的饲养和临床特征的信息，并培训兽医 利用马鞭草进行生物医学研究。动物资源核心的研究部分将重点放在 提高婴儿的生存能力。遗传学和生物行为核心将为地方和国家提供 研究人员使用多代VRC谱系和广泛的遗传和生物行为数据库 关于单个动物的信息，并将为外部研究人员提供统计遗传学支持 利用这一资源来寻找影响生物医学特征的基因。《遗传学》的研究组成部分和 生物行为核心将有助于马鞭草作为肥胖、糖尿病和新陈代谢模型的发展 综合症。这些努力将产生关键信息，并提供接触动物和研究的途径 机会将扩大使用鞭毛虫作为研究非人类灵长类动物的替代模型 人类的疾病和紊乱。

EXCEED THE SPACE PROVIDED. The critical shortage of rhesus monkeys has created an urgent need to develop alternative nonhuman primate models for biomedical research. The vervet / African green monkey (Chlorocebus aethiops) is an ideal candidate to fill this position. Vervets are Old World monkeys that resemble the rhesus in behavior, physiology and anatomy. Caribbean-derived vervets are readily available and are less expensive than rhesus, and because they do not carry Herpesvirus simiae (B virus), they present fewer health and safety risks than rhesus or other Asian macaque alternatives. The UCLA Vervet Research Colony (VRC) is an established center that has supported local research in vervet monkey neurobiology, behavior and genetics for 29 years, making it uniquely positioned to serve as the basis for a national resource center for vervet monkeys. The extensive genetic and behavioral database collected on vervets at the VRC make this a particularly valuable resource for collaborative research in a number of areas of biomedical interest, including obesity, diabetes, aging, psychiatric and behavioral disorders, and vulnerability for cardiovascular disease. Support from an NCRR P40 grant will enable the VRC to a) increase the supply of nonhuman primates for biomedical research by breeding US colony-born, specific pathogen free (SPF) vervets of known age and medical history for NIH-funded investigators; b) provide vervets with specific characteristics and conditions (e.g., aged, impulsive, obese, diabetic) to outside investigators; c) maintain a pedigreed, genotyped colony of vervets for use as a national resource for research on genetic contributions to faiomedicaltraits; d) provide training and information on the clinical care and management of vervets to enhance the use of this species in other centers, and e) support the continued use of vervet models for genetic, biobehavioral and neurobiological research, and the development of new vervet models for research in obesity, diabetes and metabolic syndrome. Two cores have been organized to accomplish these aims. The Animal Resources Core will manage the animal care and breedingprogram, maintain the colony record system, disseminate information on husbandry and clinicalcharacteristics of vervet monkeys, and train veterinarians in the use of vervets for biomedical research. The research component of the Animal Resources Core will focus on increasing infant viability. The Genetics and BiobehavioralCore will provide access for local and national investigators to use the multigenerational VRC pedigree and extensive database of genetic and biobehavioral information available on individual animals, and will provide statistical genetics support for outside investigators to use this resource to find genes that influence biomedical traits. The research component of the Genetics and Biobehavioral Core will contribute to the development of the vervet as a model for obesity, diabetes and metabolic syndrome. These efforts will generate critical information and provide access to animals and research opportunities that will expand the use of the vervet as an alternative nonhuman primate model for the study of human diseases and disorders.