Heparin Induced Thrombocytopenia (HIT): further characterization of disease mechanism will improve patient treatment

肝素诱导血小板减少症（HIT）：疾病机制的进一步表征将改善患者治疗

• 批准号: nhmrc : 1109745
• 负责人: Prof Beng Chong
• 金额: $ 31.3万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/heparin-induced-thrombocytopenia-patient-treatment/663094
• 关键词: Heparin; Induced; Thrombocytopenia; HIT; further

Thrombus formation occurs as a side effect of heparin treatment in many patients. This condition is called Heparin Induced Thrombocytopenia (HIT). The clots may be stabilised by secretions from cells called neutrophils. In this project we will study this possibility using a mouse model of HIT and will explore therapeutic approaches to inhibit clot stabilisation.

在许多患者中，血栓形成是肝素治疗的副作用。这种情况被称为肝素诱导的血小板减少症(HIT)。这种凝块可以通过称为中性粒细胞的细胞分泌物稳定下来。在这个项目中，我们将使用HIT的小鼠模型来研究这种可能性，并将探索抑制血栓稳定的治疗方法。