Drug-induced immune thrombocytopenia: Understanding the disease mechanisms is the key to better treatment

药物引起的免疫性血小板减少症：了解疾病机制是更好治疗的关键

• 批准号: nhmrc : 1012409
• 负责人: Prof Beng Chong
• 金额: $ 33.98万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/drug-induced-immune-better-treatment/109655
• 关键词: Drug; induced; immune; thrombocytopenia; Understanding

Many very commonly used medications cause an allergic reaction in a small number of patients that receive them. The allergic reaction results in platelets being destroyed and puts the patients at risk of bleeding. The patient recovers slowly if the drug is stopped but there is no other treatment and no way to reverse the effect quickly if the patient starts to bleed. This project will try to understand the mechanism of the condition and test a potential treatment.

许多非常常用的药物在接受治疗的少数患者中会引起过敏反应。过敏反应会导致血小板被破坏，并使患者面临出血的风险。如果停药，患者恢复得很慢，但没有其他治疗方法，也没有办法在患者开始出血时迅速逆转效果。这个项目将试图了解这种情况的机制，并测试一种潜在的治疗方法。